Activation of genes for growth factors and cyclooxygenases in rat gastric mucosa during recovery from stress damage

European Journal of Pharmacology
P C KonturekE G Hahn

Abstract

Growth factors and prostaglandins protect the gastric mucosa against stress-induced lesions but their role in the recovery of the mucosa from these lesions has been little studied. We evaluated gastric mucosa lesions, gastric blood flow, mucosal generation of prostaglandin E2 and mucosal gene expression of epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) as well as constitutive prostaglandin cyclooxygenase-1 and inducible cyclooxygenase-2 and the effect of the inhibition of these enzymes on the recovery of mucosa from the stress-induced lesions. Rats were exposed to 3.5 h of water immersion and restraint stress and killed at 0, 2, 4, 6, 8, 12 and 24 h after stress. The number of gastric lesions was determined and gastric blood flow was measured by H2-gas clearance. Gastric acid secretion was tested in separate gastric fistula rats. Gastric mucosa biopsies were taken for determination of immunoreactive EGF and TGF alpha. Expression of EGF and TGF alpha mRNA and cyclooxygenase-1 and cyclooxygenase-2 mRNA was also determined by reverse-transcriptase polymerase chain reaction. The number of gastric lesions induced by 3.5 h stress averaged approximately 20 per rat and declined significantly at 2, 4, 6, ...Continue Reading

References

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Citations

Sep 17, 2002·European Journal of Pharmacology·Peter C KonturekStanislaw J Konturek
Feb 12, 2005·The British Journal of Nutrition·A C B PaulaA R M Souza Brito
Feb 24, 1999·Inflammatory Bowel Diseases·P L Beck, D K Podolsky
Apr 25, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ana Claudia B De PaulaAlba R M Souza Brito
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Jingjing XuJiyang Dong
Dec 14, 2005·Pharmacology, Biochemistry, and Behavior·Jin Sheng GuoMarcel Wing Leung Koo
Jun 13, 2003·Clinics in Chest Medicine·Sigrid Carlen Veasey
Aug 24, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Mohd Fahami Nur AzlinaHj Mohd Saad Qodriyah
Sep 22, 2017·World Journal of Gastroenterology : WJG·Mohd Fahami Nur AzlinaYusof Kamisah
May 23, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nonthalee PausawasdiAndrea Todisco
Oct 18, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Barbara M AldermanAndrew S Giraud
Apr 20, 2001·European Journal of Medicinal Chemistry·G Dannhardt, W Kiefer

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