Activation of growth hormone short loop negative feedback delays puberty in the female rat

Endocrinology
J P AdvisS R Ojeda

Abstract

Implantation of GH in the median eminence of the hypothalamus of 23-day-old female rats tonically inhibited serum GH levels throughout prepubertal development (days 23-36) and depressed GH diurnal pulsatile release. Puberty was significantly delayed in GH-deficient animals, a delay associated with a blunted in vitro ovarian steroidal responsiveness to gonadotropins (particularly estradiol) and a marked decrease in prepubertal uterine weight, as evaluated 4, 7, and 13 days after GH implantation. The prepubertal body weight increase was also depressed. Neither ovarian weight nor serum levels of LH, FSH, PRL, or TSH were consistently altered by the GH implant. In addition, evaluation of pulsatile PRL release in 33-day-old rats revealed no difference between control and GH-deficient animals. Ovarian LH receptor content was lower in GH-implanted rats than in controls, suggesting that a decrease in LH receptors may be one of the mechanisms by which a chronic decrease in serum gH depressed the prepubertal ovarian estradiol and, to a lesser extent, the progesterone response to gonadotropins. A direct ovarian site of action for GH was indicated by the results of experiments in which GH was administered to immature hypophysectomized estr...Continue Reading

Citations

Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Karin A SlotKatja J Teerds
Dec 1, 1996·Journal of Endocrinological Investigation·P G ArtiniG D'Ambrogio
Jan 1, 1988·Molecular and Cellular Endocrinology·L A HutchinsonA C Herington
Jun 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·Z Blumenfeld
Mar 19, 2004·Biology of Reproduction·Varadaraj ChandrashekarAndrzej Bartke
Jun 17, 2000·Trends in Endocrinology and Metabolism : TEM·G V Childs
Apr 1, 1996·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·N DoldiA Ferrari
Dec 3, 2003·Annals of the New York Academy of Sciences·Bessie E Spiliotis
Jun 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·Z ShohamH S Jacobs
Jun 1, 1993·Baillière's Clinical Obstetrics and Gynaecology·R Homburg
Sep 1, 1990·Baillière's Clinical Obstetrics and Gynaecology·B Lunenfeld, V Insler
Jul 1, 1993·Fish Physiology and Biochemistry·F Le GacC Weil
Jan 30, 2004·American Journal of Reproductive Immunology : AJRI·Marco SbraciaUgo Di Tondo
Jul 1, 1985·The American Journal of Physiology·J B DavorenC H Li
Sep 1, 1993·Molecular and Cellular Endocrinology·B CarlssonH Billig

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.