Activation of hemostasis after coronary artery bypass grafting with or without cardiopulmonary bypass.

Anesthesia and Analgesia
Bernard LoArno P Nierich

Abstract

Activation of coagulation, fibrinolysis, and the vascular endothelium occurs after heart surgery with cardiopulmonary bypass (CPB), but the effects of eliminating CPB in patients undergoing coronary artery bypass grafting (CABG) are unknown. Therefore, we compared the hemostatic profiles of off-pump and on-pump CABG patients. Two groups of consecutive patients participating in a larger trial (the Octopus Trial) were randomly allocated to undergo CABG with (n = 20) or without (n = 20) CPB. Platelet numbers and plasma concentrations of P-selectin, prothrombin fragment 1.2 (F1.2), soluble fibrin, d-dimers, and von Willebrand factor (as a marker of endothelial cell activation) were measured and corrected for hemodilution. Compared with the on-pump CABG group, F1.2 and d-dimer levels were significantly lower (P = 0.004 and P = 0.03, respectively) in patients having CABG surgery performed off-pump. In the CPB group, F1.2 (median [interquartile range], 450% of baseline [233%-847%]) and d-dimer (538% [318%-1192%]) peaked in the immediate postoperative period and remained increased until Day 4, whereas in the off-pump group, F1.2 and d-dimer levels increased more gradually and peaked on Day 4 (342% [248%-515%] and 555% [387%-882%], resp...Continue Reading

References

Sep 1, 1991·Anesthesiology·C S RinderR Hillman
Feb 1, 1993·The Annals of Thoracic Surgery·J ButlerS Westaby
Apr 4, 1998·The Annals of Thoracic Surgery·B J HuntM Yacoub
Jun 17, 1998·The Journal of Thoracic and Cardiovascular Surgery·S R GundryL L Bailey
Sep 4, 1999·The Annals of Thoracic Surgery·R AscioneG D Angelini
Jan 3, 2001·Anesthesiology·C M SamamaP Coriat
Jun 1, 2001·The Annals of Thoracic Surgery·N TabuchiA Shibamiya
Sep 22, 2001·The Annals of Thoracic Surgery·K B KimY B Park
Mar 21, 2002·JAMA : the Journal of the American Medical Association·Diederik Van DijkUNKNOWN Octopus Study Group
May 9, 2002·The Annals of Thoracic Surgery·Mitchell J MageeMichael J Mack
Sep 24, 2002·Perfusion·R L QuigleyR Y Highbloom

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Citations

Jul 3, 2010·European Heart Journal·Miguel Sousa UvaManuel Pedro Magalhães
Dec 2, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Shreosee RoyGargi Raychaudhuri
Jan 15, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Ravi TanejaClaudio M Martin
Aug 25, 2009·The Journal of Thoracic and Cardiovascular Surgery·Marketa Hecht-DolnikJohn Loftus
Jul 30, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Jain Bhaskara Pillai, Rakesh M Suri
Jun 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Andrea BallottaRajendra H Mehta
Aug 18, 2005·Seminars in Thoracic and Cardiovascular Surgery·Hratch KarmanoukianNader D Nader
Jan 24, 2006·Journal of Cardiac Surgery·Shahzad G Raja, Gilles D Dreyfus
Mar 5, 2013·Artificial Organs·Kang ZhouZhongjun J Wu
Jan 26, 2006·The Journal of Thoracic and Cardiovascular Surgery·Domenico PaparellaStephanie J Brister
Oct 6, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Shahzad G Raja
Aug 18, 2005·Seminars in Hematology·Bruce D Spiess
Jan 28, 2010·The Annals of Thoracic Surgery·Domenico PaparellaMario Colucci
Jan 28, 2010·The Annals of Thoracic Surgery·Linda Shore-Lesserson
May 11, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Sumeet ReddyPaul Young
Apr 3, 2008·Asian Cardiovascular & Thoracic Annals·Shahzad G Raja, Gilles D Dreyfus
Dec 4, 2010·Anesthesia and Analgesia·Susanne LisonRaimund Busley
Jul 18, 2008·Anesthesia and Analgesia·Lisa T NewsomeRoger L Royster
Oct 18, 2011·Anesthesia and Analgesia·Roman M Sniecinski, Wayne L Chandler
Mar 16, 2012·The Cochrane Database of Systematic Reviews·Christian H MøllerChristian Gluud
Sep 1, 2010·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Gregory D Trachiotis
Apr 18, 2009·Anesthesia and Analgesia·Kenichi A TanakaJerrold H Levy
Sep 30, 2015·Journal of Cardiovascular Medicine·Alessandro ParolariElena Tremoli
May 27, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hakeem YusuffDaniel Brodie
Aug 3, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hakeem YusuffDaniel Brodie
Jun 18, 2014·Journal of Biomaterials Applications·Terry C MajorRobert H Bartlett

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