Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice

Molecular Metabolism
Camille AllardFranck Mauvais-Jarvis

Abstract

The endogenous estrogen 17β-estradiol (E2) promotes metabolic homeostasis in premenopausal women. In a mouse model of post-menopausal metabolic syndrome, we reported that estrogens increased energy expenditure, thus preventing estrogen deficiency-induced adiposity. Estrogens' prevention of fat accumulation was associated with increased serum concentrations of fibroblast growth factor 21 (FGF21), suggesting that FGF21 participates in estrogens' promotion of energy expenditure. We studied the effect of E2 on FGF21 production and the role of FGF21 in E2 stimulation of energy expenditure and prevention of adiposity, using female estrogen receptor (ER)- and FGF21-deficient mice fed a normal chow and a cohort of ovariectomized women from the French E3N prospective cohort study. E2 acting on the hepatocyte ERα increases hepatic expression and production of FGF21 in female mice. In vivo activation of ERα increases the transcription of Fgf21 via an estrogen response element outside the promoter of Fgf21. Treatment with E2 increases oxygen consumption and energy expenditure and prevents whole body fat accumulation in ovariectomized female WT mice. The effect of E2 on energy expenditure is not observed in FGF21-deficient mice. While E2 tr...Continue Reading

Citations

Nov 23, 2019·Diabetologia·Blandine TramuntPierre Gourdy
Jan 1, 2021·Critical Reviews in Clinical Laboratory Sciences·Yasaman Badakhshi, Tianru Jin
Mar 5, 2021·Vavilovskiĭ Zhurnal Genetiki I Selekt︠s︡ii·T V IakovlevaN M Bazhan
Mar 20, 2021·Antioxidants & Redox Signaling·Andrea Morán-CostoyaAdamo Valle
May 18, 2021·Frontiers in Cardiovascular Medicine·Yingjie CheeRinkoo Dalan
Jun 11, 2021·Journal of Animal Physiology and Animal Nutrition·Yan DengJiwen Wang
Jul 8, 2021·American Journal of Physiology. Endocrinology and Metabolism·Yasaman BadakhshiTianru Jin
Nov 19, 2021·Endocrine Reviews·Franck Mauvais-JarvisEllis R Levin

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Datasets Mentioned

BETA
GM104940

Methods Mentioned

BETA
serum collection
NMR
contraception

Software Mentioned

OligoMatch

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