Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Nidal MuhannaRifaat Safadi

Abstract

Increased CD8-T lymphocytes and reduced natural killer (NK) cells contribute to hepatic fibrosis. We have characterized pathways regulating the interactions of human hepatic stellate cells (HSCs) with specific lymphocyte subsets in vivo and in vitro. Fluorescence-activated cell sorting (FACS) was used to characterize human peripheral blood lymphocytes (PBLs) and intrahepatic lymphocytes (IHLs) obtained from healthy controls and from patients with either hepatitis B virus (HBV) or hepatitis C virus (HCV) with advanced fibrosis. Liver sections were analyzed by immunohistochemistry and confocal microscopy. To investigate in vitro interactions, PBLs from healthy controls or patients with HCV cirrhosis were co-cultured with an immortalized human HSC line (LX2 cells) or with primary HSCs. Significant alterations in lymphocyte distribution were identified in IHLs but not PBLs. The hepatic CD4/CD8 ratio and NK cells were significantly reduced in HBV/HCV patients. Expression of alpha-smooth muscle actin and infiltration of CD4, CD8, and NK cells were readily apparent in liver sections from patients with cirrhosis but not in healthy controls. Lymphocytes from each subset were in proximity to HSCs primarily within the periportal regions, ...Continue Reading

References

Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L FriedmanG Yamasaki
Feb 1, 1990·Seminars in Liver Disease·A M Gressner, M G Bachem
Apr 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Matsuoka, H Tsukamoto
Aug 1, 1993·Journal of Interferon Research·Z Reiter
Jan 1, 1995·International Journal of Clinical & Laboratory Research·L LombardoP Vineis
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Oct 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J NapoliG W McCaughan
Apr 1, 1997·Digestive Diseases and Sciences·A TranP Rampal
Oct 27, 1997·Clinical and Experimental Immunology·J CoradoJ B De Sanctis
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Jul 28, 1999·Seminars in Liver Disease·M J Koziel
Sep 2, 1999·Alcoholism, Clinical and Experimental Research·F J LasoA Orfao
Jan 6, 2000·Journal of Hepatology·C FerrariF Fiaccadori
May 3, 2000·The Journal of Experimental Medicine·F LechnerB D Walker
May 12, 2000·Immunological Reviews·N M ValianteS Abrignani
May 24, 2000·The Journal of Infectious Diseases·N H GrünerG R Pape
Oct 26, 2000·Nature·J Savill, V Fadok
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N KawarabayashiH Mochizuki
Feb 24, 2001·Gastroenterology·W Z MehalI N Crispe
Jun 16, 2001·Clinical Biochemistry·P M Jacobson Brown, M G Neuman
Oct 5, 2001·Seminars in Liver Disease·J P Iredale
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Z Q YaoY S Hahn
Nov 21, 2001·The Journal of Experimental Medicine·R ThimmeF V Chisari
Dec 6, 2001·Nature Reviews. Molecular Cell Biology·M Fukata, K Kaibuchi
Jan 10, 2002·The Journal of Experimental Medicine·Stefania CrottaNicholas M Valiante
Jan 10, 2002·The Journal of Experimental Medicine·Chien-Te K Tseng, Gary R Klimpel
Aug 8, 2002·Journal of Immunological Methods·Maike HöppnerChristoph Frohn
Dec 13, 2002·Nature·Sandrine Etienne-Manneville, Alan Hall
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pavel TaimrGregory J Gores
Jan 7, 2003·Methods in Cell Biology·T Clark BreljeRobert L Sorenson
May 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ali CanbayGregory J Gores
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Odette ViñasJuan Rodés
Apr 2, 2004·Gastroenterology·Stuart J ForbesMalcolm R Alison
Jul 24, 2004·Clinical and Experimental Immunology·A W LinA H Talal
Aug 7, 2004·Current Microbiology·M TarshisS Rottem

❮ Previous
Next ❯

Citations

Jun 30, 2010·Nature Reviews. Gastroenterology & Hepatology·Scott L Friedman
Jul 29, 2010·Seminars in Liver Disease·Wajahat Mehal, Avlin Imaeda
Apr 28, 2009·Current Opinion in Gastroenterology·Jingjing JiaoCostica Aloman
Jan 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bin GaoSamir Zakhari
Mar 11, 2009·Journal of Biomedical Science·Pablo MatarGuillermo Mazzolini
Feb 26, 2014·Nature Reviews. Immunology·Antonella PellicoroJonathan A Fallowfield
Mar 22, 2014·International Journal of Molecular Sciences·Anette Brass, Erwin Daniel Brenndörfer
Dec 18, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Bei ZhongXiang Gao
Jun 12, 2014·Fibrogenesis & Tissue Repair·Dola DasLaura E Nagy
Apr 23, 2014·Apoptosis : an International Journal on Programmed Cell Death·Thijs FeuthJoop E Arends
Jan 22, 2013·Mitochondrion·Nidal MuhannaRifaat Safadi
Nov 16, 2010·Annual Review of Pathology·Virginia Hernandez-Gea, Scott L Friedman
Mar 23, 2013·Annual Review of Immunology·Georg WickDolores Wolfram
Sep 3, 2010·Gastroenterology Research and Practice·John EvankovichAllan Tsung
Jun 18, 2009·Seminars in Immunopathology·Fabio MarraAngela Provenzano
Jul 30, 2015·International Reviews of Immunology·Yi ZhangBing Ni
Feb 6, 2016·Journal of Immunotoxicology·Sherin Zakaria, Alaa El-Sisi
Dec 3, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yannan QinZheng Li
Aug 21, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Forough KhademJude E Uzonna
Oct 4, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Partha MukhopadhyayPal Pacher
Jan 29, 2010·Trends in Immunology·Georg WickRoswitha Sgonc
Jan 13, 2009·Antiviral Research·Kathie-Anne Walters, Michael G Katze
Feb 11, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ogyi ParkBin Gao
Oct 28, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Miroslaw KornekDetlef Schuppan
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Hyon-Seung Yi, Won-Il Jeong
Nov 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhigang TianBin Gao
Dec 12, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Johnny AmerRifaat Safadi
Mar 4, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Costica Aloman, Frank Tacke
Apr 30, 2013·Journal of Hepatology·Bettina LanghansUlrich Spengler
Sep 28, 2012·Clinical Science·Daniel GrimmRobert Thimme
Feb 6, 2014·Oncoimmunology·Jana C Mossanen, Frank Tacke
May 9, 2015·International Journal of Inflammation·Florent DuvalDelia Elva Cruz-Vega
Aug 8, 2014·Frontiers in Pharmacology·Jun XuTatiana Kisseleva
Aug 20, 2016·Archives of Toxicology·Tomislav HorvatMaurice Whelan
Sep 27, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Q WangY B Zhou
Mar 9, 2018·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Johnny AmerRifaat Safadi

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