Activation of HHV-6 in lymphoproliferative disorders: a polymerase chain reaction-based study

Annals of the New York Academy of Sciences
P B TailorR Mukhopadhyaya

Abstract

HHV-6 is a latent herpes virus persisting throughout the adult life of the infected host in an integrated form and is often activated in immunocompromised situations. Detection of HHV-6 DNA in the plasma of an individual indicates the presence of active viral replication in the host. Because lymphomas are known to be associated frequently with host immunosupression, we studied activation of HHV-6 in 98 patients diagnosed with Hodgkin's disease (HD) or non-Hodgkin's lymphoma (NHL). HHV-6 activation was documented in 34% of cases of non-Hodgkin's lymphoma and 39% of those of Hodgkin's disease; however, no correlation of activation status with pathological types of Hodgkin's disease and between copy numbers in peripheral blood mononuclear cell DNA and the corresponding plasma DNA was noticeable.

References

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Citations

Aug 13, 2005·Proceedings. Biological Sciences·Alison P Galvani
Apr 14, 2010·PLoS Biology·Paul R Ehrlich
Sep 22, 2005·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Sayaka MoriShimeru Kamihira

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