Activation of Hox genes during caudal regeneration of the polychaete annelid Platynereis dumerilii.

Development Genes and Evolution
Kathrin PfeiferAndreas C Fröbius

Abstract

The capability of regenerating posterior segments and pygidial structures is ancestral for annelids and has been lost only a few times within this phylum. As one of the three major segmented taxa, annelids enable us to monitor reconstruction of lost tissues and organs. During regeneration, regional identities have to be imprinted onto the newly formed segments. In this study, we show spatial and temporal localization of expression of nine Hox genes during caudal regeneration of the polychaete annelid Platynereis dumerilii. Hox genes are homeodomain genes encoding transcriptional regulators of axial patterning in bilaterian animals during development. We demonstrate that five Platynereis Hox genes belonging to paralog groups (PG) 1, 4, 5, 6, and 9-14 are expressed in domains of the regenerating nervous system consistent with providing positional information along the anteroposterior axis of the regenerate. We report that expression in regenerating neuromeres is limited to varying subsets of perikarya, called gangliosomes. Four of nine genes analyzed do not appear to be involved in axial patterning. Two genes, Pdu-Hox2 and Pdu-Hox3, are predominantly expressed in the growth zone region. For some Hox genes expression in newly form...Continue Reading

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Citations

May 3, 2013·EvoDevo·Nadezhda I BakalenkoMilana A Kulakova
Mar 17, 2015·Development Genes and Evolution·Vitaly V Kozin, Roman P Kostyuchenko
Aug 10, 2016·Current Opinion in Genetics & Development·B Duygu Özpolat, Alexandra E Bely
Apr 4, 2017·PLoS Genetics·Patricia Mendoza-GarcíaRuth H Palmer
Jan 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrey FadeevRuth H Palmer
May 4, 2018·Regeneration·Rannyele P RibeiroM Teresa Aguado
Aug 11, 2018·Evolution & Development·Guillermo Ponz-SegrellesM Teresa Aguado
Mar 7, 2021·International Journal of Molecular Sciences·Kornélia BodóPéter Engelmann
Sep 29, 2021·EvoDevo·B Duygu ÖzpolatDetlev Arendt
Oct 8, 2021·Biological Reviews of the Cambridge Philosophical Society·Baruch RinkevichBert Hobmayer

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