PMID: 63142Jan 1, 1976Paper

Activation of human lymphocyte subpopulations by rabbit anti-human beta2-microglobulin and by lipopolysaccharide

Scandinavian Journal of Immunology
O Ringdén

Abstract

Rabbit anti-human beta2-microglobulin (anti-beta2m) was found to increase DNA synthesis in peripheral blood lymphocytes (PBLs) and in cells from abdominal lymph nodes, spleen, tonsil, adenoid, appendix, and bone marrow. The response to anti-beta2m was highest in cells originating from abdominal lymph node, appendix, and spleen. These organs were shown to contain a high proportion of surface-Ig-positive cells. No response to anti-beta2m was seen in thymus cells or in B-cell-depleted lymphocyte populations. Lipopolysaccharide (LPS) increased DNA synthesis in spleen cells, bone marrow cells, tonsil cells, and, sometimes, in cells from abdominal lymph nodes but weakly or not at all in PBLs. To study whether anti-beta2m and LPS activated the same subpopulation of lymphocytes, cultures were exposed to both mitogens in various concentrations. The effect on DNA synthesis in spleen cells was almost additive. This may indicate that these two polyclonal B-cell activators (PBAs) stimulate mainly distinct subsets of B cells in spleen. On the other hand, these two mitogens have a synergistic effect on DNA synthesis in PBLs. Since anti-beta2m is the first described selective B-cell mitogen activating human PBLs, it might be of clinical import...Continue Reading

References

Jan 1, 1975·Scandinavian Journal of Immunology·O Ringeén, E Möller
Sep 1, 1975·Scandinavian Journal of Immunology·H Blomgren
Mar 1, 1973·The Journal of Experimental Medicine·T H HütterothM D Poulik
Dec 1, 1973·The Journal of Experimental Medicine·H M GreyJ L Strominger
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonJ B Lindblom
Jan 1, 1974·Tissue Antigens·B G Solheim, E Thorsby
Jan 1, 1972·Immunological Communications·S A EisenC W Parker
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·K NakamuroD Pressman
Jan 1, 1974·Scandinavian Journal of Immunology·E Möller, U Persson
Jul 1, 1974·The Journal of Experimental Medicine·M GreavesM Doenhoff
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton

❮ Previous
Next ❯

Citations

Aug 1, 1978·British Journal of Haematology·D G Newell, S Roath
Jan 1, 1979·Immunological Reviews·R S Geha
Aug 1, 1976·Kidney International·L J QuadracciM Krzymanski
Oct 1, 1989·Scandinavian Journal of Immunology·J TollemarK Holmberg
Jan 1, 1980·Scandinavian Journal of Immunology·O Ringdén
Jan 1, 1981·Scandinavian Journal of Immunology·J KinnmanH Link
Dec 1, 1985·Scandinavian Journal of Immunology·L Hammarström, C I Smith
Jan 1, 1982·Acta paediatrica Scandinavica·G KälleniusP Sundelin
Dec 9, 2003·Journal of Biochemistry and Molecular Biology·Laila N Islam, A H M Nurun Nabi
Nov 13, 2004·Clinical Science·Anna JanuszkiewiczJan Wernerman
Jan 1, 1978·European Journal of Immunology·O Ringdén, Rynnel-Dagöö
Jan 1, 1981·Acta Medica Scandinavica·A Wirfält
Oct 8, 2020·International Journal of Molecular Sciences·Francesco SabbatinoStefano Pepe
Nov 15, 1977·Life Sciences·Z Likovský, Z Konícková

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.