PMID: 8608156Mar 29, 1996Paper

Activation of human plasma cholesteryl ester transfer protein by human apolipoprotein A-IV

Biochimica Et Biophysica Acta
L A MainS Yokoyama

Abstract

Function of apolipoprotein (apo) A-IV was studied for its role in cholesteryl ester transfer protein (CETP; lipid transfer protein, LTP) reaction between lipid microemulsions having the diameter of low density lipoprotein, being compared to apoA-I. CETP hardly catalyzed lipid transfer without apolipoproteins. ApoA-IV bound to the surface of the microemulsion in equilibrium with a similar affinity to that of other helical apolipoproteins, and activated the transfer reaction by CETP of cholesteryl ester, triacylglycerol and phosphatidylcholine between the emulsions. The rate of the transfer reaction of cholesteryl ester and triacylglycerol was directly proportional to the amount of the bound apoA-IV to the surface of the emulsion. For phosphatidylcholine, activation was less effective until 40% of total binding capacity of lipid emulsion was occupied by the apolipoprotein. Cholesteryl ester was highly preferred by CETP over triacylglycerol when equal amount of these lipids was present in the core of the apoA-IV-activated emulsion, resulting in almost no triacylglycerol transfer. However, when the emulsion has the core exclusively of triacylglycerol, triacylglycerol was transferred by CETP with the rate in the same order as that o...Continue Reading

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Citations

Dec 17, 1997·Clinical Biochemistry·S A Hill, M J McQueen
Jul 18, 2002·Clinical Genetics·I A LarsonE J Schaefer
Aug 18, 2005·Kidney International·Marina HaimanHans Dieplinger
Apr 24, 2008·The Journal of Biological Chemistry·Matthew R TubbW Sean Davidson
Feb 2, 2010·Biochemical and Biophysical Research Communications·Monica GomaraschiLaura Calabresi
Dec 16, 2011·Journal of Biochemistry·Ji Yoon ParkSeung-Taek Lee
Apr 23, 2005·Biochemical and Biophysical Research Communications·Minna T JänisChristian Ehnholm
Dec 7, 2013·The Journal of Biological Chemistry·Xiaoming LiPatrick Tso
Oct 26, 2012·Molecular Biology Reports·Filiz Guclu-GeyikNihan Erginel-Unaltuna
Oct 12, 2021·Journal of Lipid Research·Baohai ShaoUNKNOWN Michigan Kidney Translational Core CPROBE Investigator Group

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