Abstract
Odorants are non-nutrients. However, they exist abundantly in foods, wines, and teas, and thus can be ingested along with the other nutrients during a meal. Here, we have focused on the chemical-recognition ability of these ORs and hypothesized that the odorants ingested during a meal may play a physiological role by activating the gut-expressed ORs. Using a human-derived enteroendocrine L cell line, we discovered the geraniol- and citronellal-mediated stimulation of glucagon-like peptide-1 (GLP-1) secretion and elucidated the corresponding cellular downstream signaling pathways. The geraniol-stimulated GLP-1 secretion event in the enteroendocrine cell line was mediated by the olfactory-type G protein, the activation of adenylyl cyclase, increased intracellular cAMP levels, and extracellular calcium influx. TaqMan qPCR demonstrated that two ORs corresponding to geraniol and citronellal were expressed in the human enteroendocrine cell line and in mouse intestinal specimen. In a type 2 diabetes mellitus mouse model (db/db), oral administration of geraniol improved glucose homeostasis by increasing plasma GLP-1 and insulin levels. This insulinotropic action of geraniol was GLP-1 receptor-mediated, and also was glucose-dependent. T...Continue Reading
References
Apr 5, 1991·Cell·L Buck, R Axel
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O ThastrupA P Dawson
Oct 1, 1996·Neuron·L J BrunetJ Ngai
Aug 18, 2001·Cell·G NelsonC S Zuker
Sep 21, 2001·Endocrinology·R A ReimerK Macé
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 12, 2002·Journal of Neuroscience Research·Martina WeberJörg Strotmann
Nov 28, 2002·Diabetes·Yi PangRichard B Marchase
Mar 29, 2003·Science·Marc SpehrHanns Hatt
Jan 30, 2004·Journal of Neurobiology·Joji M OtakiStuart Firestein
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bettina MalnicLinda B Buck
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Weihong LinDiego Restrepo
Aug 19, 2004·Journal of Agricultural and Food Chemistry·Dawn M ChapmanSusan E Ebeler
Jan 14, 2005·Chemical Senses·Guenhaël SanzLoïc Briand
May 9, 2007·Gastroenterology·Thomas BraunManfred Gratzl
May 19, 2007·Genome Biology·Xiaohong ZhangYoav Gilad
Jul 3, 2007·Journal of Structural Biology·Kristin SchmiedebergDietmar Krautwurst
Aug 8, 2007·Biochemical and Biophysical Research Communications·Anna StaryGerhard Buchbauer
Aug 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hyeung-Jin JangJosephine M Egan
Jun 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark KiddRoswitha Pfragner
Jul 19, 2008·The Journal of Biological Chemistry·Diva D De LeónDoris A Stoffers
Jan 1, 1977·Neuroscience Letters·S Price
Nov 20, 2009·Developmental Cell·Christine A GriffinGrace K Pavlath
Mar 17, 2012·The Journal of Pharmacy and Pharmacology·Tatiana Fernanda BachiegaJosé Maurício Sforcin
Apr 10, 2012·Cell Metabolism·Frank ReimannFiona M Gribble
Aug 3, 2012·Diabetes·Andrew C CalabriaDiva D De León
Jul 14, 2014·Diabetologia·Ki-Suk KimHyeung-Jin Jang
Nov 28, 2014·American Journal of Physiology. Cell Physiology·Ningyong XuTroy Stevens
Apr 3, 2015·Physiological Reviews·Darleen A Sandoval, David A D'Alessio
Dec 18, 2015·Scientific Reports·Ki-Suk KimHyeung-Jin Jang
Mar 23, 2017·Cell Metabolism·Adam P ChambersDarleen A Sandoval
Citations
Dec 7, 2018·Nature Reviews. Drug Discovery·Sung-Joon LeeHanns Hatt
Feb 29, 2020·International Journal of Molecular Sciences·Sachiko Koyama, Thomas Heinbockel
Apr 6, 2018·Genomics & Informatics·S June Oh
Oct 10, 2018·Frontiers in Pharmacology·Kang-Hoon KimHyeung-Jin Jang
Jan 24, 2019·Toxins·Kent M ReedRoger A Coulombe
Sep 12, 2018·Genes & Genomics·Chang Soo RyuNam Keun Kim
Jan 21, 2021·Frontiers in Cell and Developmental Biology·Elisabeth UrbauerDirk Haller
Feb 20, 2021·Critical Reviews in Food Science and Nutrition·Rifat Nowshin RakaJianming Jin
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jocelijn Meijerink
Apr 16, 2021·Bio-protocol·Snehal N Chaudhari, A Sloan Devlin
Aug 14, 2021·Critical Reviews in Food Science and Nutrition·José Fernando Rinaldi de AlvarengaJarlei Fiamoncini
Jul 31, 2021·Molecular Biology and Evolution·Kejun WangXiangtao Kang
Aug 29, 2021·Pharmaceutics·Tao TongKunlun Huang
Aug 20, 2021·British Journal of Pharmacology·Siyu ZhangHanbing Li
Nov 19, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryan KurtzBlythe D Shepard
Mar 17, 2021··Snehal Chaudhari, Abigail Devlin