PMID: 7546740Sep 1, 1995Paper

Activation of light-dependent K+ channels in ciliary invertebrate photoreceptors involves cGMP but not the IP3/Ca2+ cascade

Neuron
M del Pilar Gomez, Enrico Nasi

Abstract

The activation of light-dependent K+ channels in ciliary photoreceptors from Pecten was investigated using intracellular dialysis of putative messengers and modulators. Neither elevated [Ca2+] nor BAPTA changed the membrane current in the dark or the light response. IP3 and the antagonists heparin and decavanadate were similarly ineffective, indicating that in these cells the IP3/Ca2+ signaling pathway is not crucial for phototransduction. By contrast, 8-Br-cGMP and cGMP induced an outward current accompanied by an increase in membrane conductance; 8-Br-cAMP was ineffective. The identity between the cGMP-induced and the light-induced currents is suggested by the following: both are carried by K+ and blocked by 4-AP, and both show outward rectification. In addition, guanine cyclic nucleotides depressed the photoresponse and induced single-channel currents in excised patches of light-sensitive membrane. These light-dependent channels therefore appear to represent a link between the families of cyclic nucleotide-gated channels and voltage-dependent K+ channels.

References

Jun 1, 1992·The American Journal of Physiology·S DeLisleM J Welsh
Sep 1, 1992·The American Journal of Physiology·D RestrepoD L Kalinoski
Apr 1, 1992·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·U WernerB Minke
Sep 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·J BacigalupoJ E Lisman
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A L ZimmermanL Stryer
Jan 1, 1989·Annual Review of Neuroscience·K W Yau, D A Baylor
Sep 21, 1989·Nature·M J Berridge, R F Irvine
Oct 30, 1985·Biochemical and Biophysical Research Communications·H InoueY Hotta
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·O DevaryZ Selinger
Jan 1, 1988·Cold Spring Harbor Symposia on Quantitative Biology·Z Selinger, B Minke
Jul 1, 1986·The Journal of General Physiology·R PayneA Fein
Jun 1, 1973·The Journal of Clinical Endocrinology and Metabolism·L ShenkmanC S Hollander
Jan 1, 1965·Cold Spring Harbor Symposia on Quantitative Biology·R M Eakin
Sep 1, 1970·The Journal of General Physiology·J S McReynolds, A L Gorman
Jul 18, 1969·Science·A L Gorman, J S McReynolds
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·K W Yau
Jan 1, 1995·Biophysical Journal·Y KoutalosK W Yau

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Citations

Mar 14, 2007·Pflügers Archiv : European journal of physiology·David M Berson
Apr 1, 1997·Current Opinion in Cell Biology·L Y Jan, Y N Jan
Oct 18, 2003·Insect Biochemistry and Molecular Biology·Günter GisselmannHanns Hatt
Sep 12, 2006·Nature Cell Biology·Timo StrünkerU Benjamin Kaupp
Jul 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dong-Gen LuoKing-Wai Yau
Mar 1, 1997·The Journal of General Physiology·M P Gomez, E Nasi
Oct 3, 2002·The Journal of General Physiology·Tsukasa Gotow, Takako Nishi
Apr 23, 2005·The European Journal of Neuroscience·Günter GisselmannHanns Hatt
Feb 10, 2006·Annals of the New York Academy of Sciences·E Hildebrand, U B Kaupp
Jun 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sayuri TomonariHideyo Ohuchi
Feb 11, 2010·Current Biology : CB·Gordon L FainSimon B Laughlin
Oct 20, 2009·Cell·King-Wai Yau, Roger C Hardie
Sep 3, 2002·The Journal of Physiology·Giuseppe PiccoliEnrico Nasi
Jan 14, 2004·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Yoshinori Shichida, Takahiro Yamashita
Sep 12, 1997·The Journal of Biological Chemistry·D KojimaY Shichida
Jul 8, 2015·Eukaryotic Cell·Gabriela Mól AvelarSuely L Gomes
Jun 28, 2002·Physiological Reviews·U Benjamin Kaupp, Reinhard Seifert
Jan 28, 2018·The Journal of General Physiology·Oscar ArenasEnrico Nasi
Oct 3, 2018·PloS One·Tomás OsornoEnrico Nasi
Nov 13, 2009·Communicative & Integrative Biology·Enrico Nasi, María del Pilar Gomez

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