Activation of liver X receptors inhibits cadmium-induced apoptosis of human renal proximal tubular cells

Toxicology Letters
Somsak FongsupaSunhapas Soodvilai


Liver X receptors (LXRs) including LXRα and LXRβ are members of the nuclear receptor superfamily of ligand-activated transcription factors, which are expressed in high metabolic organs such as the liver, kidney, and adipose tissue. LXRs have been shown to act as antioxidants and anti-inflammatory in several organs. The present study investigated the effects of LXR activation on cadmium-induced cell death in renal proximal tubular cells. Treating human renal proximal tubular cells, HK-2 cells, with 20μM CdCl2 for 24h led to cell death via apoptosis but not necrosis. Interestingly, pretreating HK-2 cells with T0901317, a LXR agonist, significantly inhibited the apoptotic cell death induced by CdCl2. The protective effect of T0901317 was eliminated by incubation with fenofibrate, a LXR antagonist, indicating that the effect of T0901317 on cadmium-induced apoptotic cell death was mediated by LXR activation. In addition, the effect of CdCl2 was attenuated by a reactive oxygen species (ROS) scavenger, N-acetyl-l-cysteine (NAC). An increase in ROS induced by CdCl2 was mediated by inhibition of catalase but not superoxide dismutase (SOD) which was attenuated by T0901317. Western blot analysis revealed that CdCl2 stimulated expression o...Continue Reading


Oct 1, 1966·British Journal of Industrial Medicine·D C BetonG F Smith
Oct 18, 1996·The Journal of Biological Chemistry·P Gómez del ArcoJ M Redondo
Jun 22, 1999·Journal of Toxicology and Environmental Health. Part a·Z A ShaikhP Vestergaard
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 20, 2002·The Journal of Biological Chemistry·Joyce J RepaDavid J Mangelsdorf
Sep 3, 2002·Toxicology·Elisabetta CasalinoClemente Landriscina
Apr 12, 2003·Molecular Endocrinology·Peter Tontonoz, David J Mangelsdorf
Sep 16, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Lawrence H LashRudolfs K Zalups
Jan 18, 2006·Toxicology·Neelima Pathak, Shashi Khandelwal
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Feb 16, 2006·The Journal of Experimental Medicine·Farshid NoorbakhshChristopher Power
Mar 3, 2006·The Journal of Clinical Investigation·Noam Zelcer, Peter Tontonoz
Mar 17, 2006·Human & Experimental Toxicology·M FilipicM Vudrag
Mar 24, 2006·Archives of Toxicology·Hyogo HoriguchiFujio Kayama
Apr 8, 2006·Occupational and Environmental Medicine·M NishijoK Nogawa
May 27, 2006·Journal of Toxicology and Environmental Health. Part a·Jiyoung Kim, Raghubir P Sharma
Mar 27, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yan LiuYun-Qing Cai
Jun 29, 2007·American Journal of Physiology. Cell Physiology·Wing-Kee LeeFrank Thévenod
Dec 19, 2007·The Journal of Biological Chemistry·Makiko YokouchiMasanori Kitamura
May 14, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Reem H Elbekai, Ayman O S El-Kadi
Aug 8, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Nobito HiguchiMunechika Enjoji
Sep 1, 2009·The Journal of Biological Chemistry·Haibiao GongWen Xie
Apr 26, 2011·Toxicology Letters·Sunhapas SoodvilaiVaranuj Chatsudthipong
Aug 3, 2011·Archives of Toxicology·Yuta KomoikeMasato Matsuoka
Dec 16, 2011·American Journal of Physiology. Renal Physiology·Suticha KittayaruksakulVaranuj Chatsudthipong
Sep 28, 2012·Pflügers Archiv : European journal of physiology·Sarah E JenkinsonColin D A Brown
Oct 19, 2012·American Journal of Physiology. Renal Physiology·Sunhapas SoodvilaiTianxin Yang
May 31, 2013·American Journal of Physiology. Renal Physiology·Promporn RaksaseriSunhapas Soodvilai

❮ Previous
Next ❯


Oct 13, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yongxia ChengGuibo Liu
Mar 1, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ting XiongJian Tu
Nov 12, 2017·Experimental Physiology·Pattira ChonlaketSunhapas Soodvilai
Aug 2, 2018·Journal of Mammary Gland Biology and Neoplasia·Xiaoyu HuYunhe Fu
Feb 9, 2019·Environmental Science and Pollution Research International·Sumita HalderBasu D Banerjee

❮ Previous
Next ❯

Related Concepts

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis