Activation of MAP kinase cascade induced by human pancreatic phospholipase A2 in a human pancreatic cancer cell line

FEBS Letters
E KinoshitaM Sugiyama

Abstract

We have found that the growth of human pancreatic cancer cells MIAPaCa-2, induced by human pancreatic phospholipase A2 group I (hPLA2-I), is mediated via its specific receptor but not via its catalytic property. The present study showed that the activation of mitogen-activated protein kinase (MAPK) cascade in MIAPaCa-2 cells is induced by hPLA2-I: this digestive enzyme induced phosphorylation of MEK1/2, p44/42 MAPK and ATF-2, and the phosphorylation in the MAPK cascade was inhibited after the cells were pre-incubated with a selective inhibitor of MEK, PD98059. In addition, this inhibitor dose-dependently blocked the hPLA2-I-induced MIAPaCa-2 proliferation, suggesting that activation of the MAPK cascade is essential for the hPLA2-I-induced MIAPaCa-2 proliferation.

References

Jul 31, 1992·Biochemical and Biophysical Research Communications·J KishinoH Arita
Apr 23, 1992·Biochimica Et Biophysica Acta·T KanemasaH Arita
Oct 17, 1991·Nature·B J PulvererJ R Woodgett
Jan 23, 1989·Biochimica Et Biophysica Acta·T SakataM Okamoto
Apr 24, 1968·Biochimica Et Biophysica Acta·G H de HaasL L van Deenen
Jun 6, 1995·Biochemical and Biophysical Research Communications·T H Burkey, J W Regan
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G PagèsJ Pouysségur

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Citations

Dec 22, 1999·Archives of Biochemistry and Biophysics·K Hanasaki, H Arita
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Kohji Hanasaki, Hitoshi Arita
Jan 23, 1999·European Journal of Biochemistry·A Alape-GirónH Jörnvall
Apr 21, 2001·DNA and Cell Biology·A K MandalA B Mukherjee
Feb 24, 2001·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Y Yokota
Feb 7, 2009·EMBO Reports·Arnaud AugertDavid Bernard
Mar 20, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Maja RadisavljevićMarijana Petković
Oct 7, 2014·Biochimie·Vesna BrglezToni Petan
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Christopher C SillimanAnirban Banerjee
Mar 19, 2002·The Journal of Biological Chemistry·Masanori SugiyamaHideo Misaki
Apr 29, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Herbert Luke OgdenTeal S Hallstrand
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A N FontehF H Chilton
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dae-Won ParkSuk-Hwan Baek
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A K MandalA B Mukherjee
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francescopaolo GranataMassimo Triggiani
Jan 3, 2021·The FEBS Journal·Evelyn ChukwurahMaria Hatzoglou
Mar 10, 2005·Journal of Separation Science·Eiji KinoshitaTohru Koike
Sep 6, 2006·Biochimica Et Biophysica Acta·Massimo TriggianiGianni Marone

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