Activation of MAP kinase signaling pathway in the mussel Mytilus galloprovincialis as biomarker of environmental pollution

Aquatic Toxicology
A ChâtelW E G Müller

Abstract

Stimulation of MAP kinase signal transduction pathway by various stressful stimuli was investigated in the marine bivalve Mytilus galloprovincialis. Analyses were performed in animals exposed in laboratory to selected pollutants and in mussels collected in winter and summer along the eastern Adriatic coast (Croatia). Effects of oxidative stress, induced by tributyltin, hydrogen peroxide and water soluble fraction of diesel fuel on the activation/phosphorylation of the three Mitogen-Activated Protein Kinases (MAPKs) p38, JNK and ERK using a newly developed ELISA procedure were evaluated. MAP kinase activation was analyzed 1h after exposure of mussels to chemical agents, and after recovery periods of 6 and 24h. Our results clearly indicated that pollutants generated different patterns of induction of the MAPK phosphorylation. Indeed, only pp38 and pJNK were activated with 11, 33 and 100 microg/L TBT, reaching a maximum activation after 6h in seawater following treatment of mussels with 11 microg/L TBT. Treatment with 0.074 and 0.222 mM H2O2 enhanced activation of both p38 and ERK. These two kinases were activated after 1h exposure, followed by a diminution after 6h of recovery in seawater and a reactivation after 24h. The levels ...Continue Reading

References

Apr 1, 1976·Environmental Health Perspectives·R D Kimbrough
Sep 1, 1980·Journal of Toxicology and Environmental Health·O PelkonenD W Nebert
Aug 1, 1993·Analytical Biochemistry·R BatelW E Müller
Apr 16, 1998·Archives of Environmental Contamination and Toxicology·S TanabeA N Subramanian
Oct 24, 1998·Regulatory Toxicology and Pharmacology : RTP·J F CollinsA G Salmon
Jul 23, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·A M RummelB L Upham
Jul 4, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·D Kültz, K Avila
Jul 5, 2001·Journal of Toxicology and Environmental Health. Part a·V C KarpiakC L Eyer
Apr 27, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M CavalettoA Viarengo
Jun 6, 2002·Memórias do Instituto Oswaldo Cruz·S PoonamK Balaraman
Jul 11, 2002·Cell and Tissue Research·Markus BöhmWerner E G Müller
Jul 12, 2002·Microscopy Research and Technique·Laura CanesiCarla Pruzzo
Jul 16, 2002·Environmental Health Perspectives·Lisa A CarterLisa A Bonner
Oct 2, 2002·Gene·Werner E G MüllerVera Gamulin
Jun 10, 2003·The Journal of Biological Chemistry·Kouhei MasudaKunimi Kikuchi
Oct 22, 2003·Aquatic Toxicology·Zeljko Jaksić, Renato Batel
Feb 26, 2004·General and Comparative Endocrinology·Laura CanesiGabriella Gallo
Feb 27, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Davide MalagoliEnzo Ottaviani
Apr 13, 2004·Oncogene·Teiji Wada, Josef M Penninger
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Philippe P Roux, John Blenis
Jul 10, 2004·General and Comparative Endocrinology·Laura CanesiGabriella Gallo
May 14, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Gianfranco SantovitoVincenzo Albergoni
Jun 18, 2005·Marine Pollution Bulletin·Zeljko JaksićRudolf Karl Zahn
Apr 4, 2006·Aquatic Toxicology·Bruno BurlandoAldo Viarengo
Apr 8, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Laura CanesiGabriella Gallo
May 22, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Bradford C BluntPolly A Hofmann
May 25, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andreas AnestisBasile Michaelidis
Oct 20, 2007·The FEBS Journal·Diego F Fiol, Dietmar Kültz

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Citations

Jan 29, 2011·Isotopes in Environmental and Health Studies·Tjasa KanducBojan Hamer
Feb 26, 2015·Annals of the New York Academy of Sciences·Maura BenedettiFrancesco Regoli
Mar 28, 2017·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Amélie Châtel, Catherine Mouneyrac
Mar 28, 2017·Marine Drugs·Antonio Trincone
Nov 18, 2018·Bulletin of Environmental Contamination and Toxicology·Fateh MoëzziAmir Ghadermarzi
Aug 15, 2017·Marine Environmental Research·Jonny BeyerMerete Schøyen

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