Activation of maternal toll-like receptor-2 causes social deficits and memory impairment in female offspring

Neuroreport
Younghwa LeeJong Hoon Ryu

Abstract

To study the relevance of the activation of toll-like receptor-2 and abnormal behavioral properties, we introduced prenatal zymosan, a toll-like receptor-2 ligand, to investigate the effect of maternal immunity on offspring behavior. Only female offspring showed impaired social and cognitive function, suggesting that zymosan may influence females' behavior.

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