Activation of metabotropic glutamate receptors inhibits high-voltage-gated calcium channel currents of chicken nucleus magnocellularis neurons

Journal of Neurophysiology
Yong Lu, Edwin W Rubel

Abstract

Using whole cell patch-clamp recordings, we pharmacologically characterized the voltage-gated Ca2+ channel (VGCC) currents of chicken nucleus magnocellularis (NM) neurons using barium as the charge carrier. NM neurons possessed both low- and high-voltage-activated Ca2+ channel currents (HVA I(Ba2+)). The N-type channel blocker (omega-conotoxin-GVIA) inhibited more than half of the total HVA I(Ba2+), whereas blockers of L- and P/Q-type channels each inhibited a small fraction of the current. Metabotropic glutamate receptor (mGluR)-mediated modulation of the HVA I(Ba2+) was examined by bath application of glutamate (100 microM), which inhibited the HVA I(Ba2+) by an average of 16%. The inhibitory effect was dose dependent and was partially blocked by omega-conotoxin-GVIA, indicating that mGluRs modulate N and other type HVA I(Ba2+). The nonspecific mGluR agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarbosylic acid (1S,3R-ACPD), mimicked the inhibitory effect of glutamate on HVA I(Ba2+). Group I-III mGluR agonists showed inhibition of the HVA current with the most potent being the group III agonist L(+)-2-amino-4-phosphonobutyric acid. 1S,3R-ACPD (200 microM) had no effect on K+ or Na+ currents. The firing properties of NM neurons w...Continue Reading

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Citations

Jul 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luke Remage-HealeyBarney A Schlinger
Oct 4, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zheng-Quan TangYong Lu
Apr 15, 2009·The Journal of Comparative Neurology·Yuan WangEdwin W Rubel
Jun 25, 2005·The Journal of Comparative Neurology·R Michael BurgerEdwin W Rubel
Nov 24, 2020·Frontiers in Neural Circuits·Nupur GoelYong Lu

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