Activation of mitogen-activated protein kinase by protein kinase C isotypes alpha, beta I and gamma, but not epsilon

FEBS Letters
S W YoungJ M Tavaré

Abstract

Treatment of CHO.T cells with either PMA or insulin led to the activation of MAP kinase by approximately 3-fold, and p90rsk by approximately 4-fold. Over-expression of the alpha, beta I or gamma isoforms of protein kinase C caused a substantial enhancement of the effect of PMA on the activation of MAP kinase and p90rsk, however, the effect of insulin was unchanged. Over-expression of the epsilon isoform of protein kinase C did not alter the effect of either PMA or insulin on the activation of MAP kinase and p90rsk. The results suggest that protein kinase C isotypes, alpha, beta I and gamma, but not epsilon, can mediate MAP kinase activation by PMA, and strongly support the hypothesis that protein kinase C isoforms can initiate distinct signalling pathways.

References

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Citations

Jun 4, 1999·Progress in Biophysics and Molecular Biology·M H Cobb
Mar 9, 2012·The Journal of Biological Chemistry·Takeshi MinashimaThorsten Kirsch
Jul 11, 2002·The American Journal of Pathology·Ren-Feng GuoPeter A Ward
Feb 12, 1998·The Journal of Biological Chemistry·O TraubB C Berk
May 12, 1998·The American Journal of Physiology·J A MaloneyJ R Williamson
Aug 12, 1998·The American Journal of Physiology·M M MonickG W Hunninghake

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