PMID: 7541539Jul 3, 1995Paper

Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin

Proceedings of the National Academy of Sciences of the United States of America
G D'AngeloR Weiner

Abstract

A number of factors both stimulating and inhibiting angiogenesis have been described. In the current work, we demonstrate that the angiogenic factor vascular endothelial growth factor (VEGF) activates mitogen-activated protein kinase (MAPK) as has been previously shown for basic fibroblast growth factor. The antiagiogenic factor 16-kDa N-terminal fragment of human prolactin inhibits activation of MAPK distal to autophosphorylation of the putative VEGF receptor, Flk-1, and phospholipase C-gamma. These data show that activation and inhibition of MAPK may play a central role in the control of angiogenesis.

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J FolkmanB R Zetter
Sep 30, 1992·Biochemical and Biophysical Research Communications·B I TermanP Böhlen
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D J GoodN P Bouck
Feb 28, 1991·Biochemical and Biophysical Research Communications·J V OlanderJ E DeLarco
Apr 20, 1990·Cell·A Ullrich, J Schlessinger
Jan 1, 1987·Nouvelle Revue Française D'hématologie·A Camez, G Tobelem
Jun 15, 1989·Biochemical and Biophysical Research Communications·N Ferrara, W J Henzel
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·F EschR Guillemin
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T P QuinnL T Williams
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Blenis
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·G PagèsJ Pouysségur

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Citations

Dec 1, 1995·Cancer Metastasis Reviews·R S Kerbel
Apr 13, 2010·Clinical & Experimental Metastasis·Adriana AlbiniUlrich Pfeffer
Jan 22, 2008·Journal of Mammary Gland Biology and Neoplasia·Carmen ClappGonzalo Martínez de la Escalera
Jan 22, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mohamed A Bedaiwy, Tommaso Falcone
Feb 13, 2001·Fertility and Sterility·D I LebovicR N Taylor
Jan 4, 1998·Respiration Physiology·D Beitner-JohnsonD E Millhorn
Jul 20, 1999·Molecular and Cellular Endocrinology·V GoffinP A Kelly
Jul 1, 1997·Cancer Treatment Reviews·A P Jekunen, K J Kairemo
Oct 11, 2002·Free Radical Biology & Medicine·Nilanjana Maulik, Dipak K Das
Apr 18, 2003·Protein Expression and Purification·Matthew GalfioneSue-Hwa Lin
Apr 20, 2001·The International Journal of Biochemistry & Cell Biology·Y Cao
Nov 13, 2001·British Journal of Pharmacology·P N BernatchezM G Sirois
Aug 30, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ngoc-Quynh-Nhu NguyenIngrid Struman
Feb 27, 2007·Oncogene·P E DepeilleN S Duesbery
Jun 1, 1997·The British Journal of Ophthalmology·R O Schlingemann, V W van Hinsbergh
Oct 7, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Amanda J LeBlancJudy M Muller-Delp
Sep 13, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Md Ruhul AbidWilliam C Aird
Apr 27, 2013·The Journal of Clinical Investigation·Julie HalkeinIngrid Struman
Sep 15, 2009·PloS One·Jennifer L Bromberg-WhiteNicholas S Duesbery
Nov 23, 2011·The Journal of Endocrinology·Kai Wang, Jing Zheng
Sep 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ngoc-Quynh-Nhu NguyenIngrid Struman
Mar 29, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Eric M GeorgeJoey P Granger
Jun 6, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gaoxiang GeDaniel S Greenspan
May 21, 2014·Nature Reviews. Clinical Oncology·Yujie Zhao, Alex A Adjei
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·R MöhleS Rafii
Aug 30, 2014·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Masako TanakaYasuyuki Ohkawa
Jul 1, 1997·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A HayashiE de Juan
Nov 6, 2002·Journal of Neuroimmunology·Frauke ForstreuterRolf Mentlein

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