Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Y ItoM Hori

Abstract

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) is a key molecule in intracellular signal transducing pathways that transport extracellular stimuli from cell surface to nuclei. MAPK/ERK has been revealed to be involved in the physiological proliferation of mammalian cells and also to potentiate them to transform. However, its role in the outgrowth of human hepatocellular carcinoma (HCC) has yet to be clarified. Therefore, in this study, we investigated the activation of MAPK/ERK and its associated gene expression in HCC. MAPK/ERK was activated in 15 of 26 cases of HCC we examined (58%), and its activity level was significantly higher in HCC than in the adjacent non-cancerous lesions. Besides, MAPK/ERK activation in HCC was positively correlated with protein expression of transcription factor c-Fos. Furthermore, in 25 of 26 cases of HCC which genomic DNA was available, 22 cases without genomic DNA amplification exhibited positive correlation, not only between protein expression of c-Fos and cyclin D1, but also between MAPK/ERK activation and cyclin D1 expression. Concerning the relationship between MAPK/ERK activation and the clinicohistopathological features of HCC, the tumor (HCC) vers...Continue Reading

References

Mar 1, 1992·Molecular and Cellular Biology·R H ChenJ Blenis
May 17, 1991·Cell·Y XiongD Beach
Oct 17, 1991·Nature·B J PulvererJ R Woodgett
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L B Ray, T W Sturgill
Sep 1, 1986·AJR. American Journal of Roentgenology·M SumidaN Hirooka
Oct 1, 1994·Pathology, Research and Practice·A NoëlJ M Foidart
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·J Benn, R J Schneider
Oct 29, 1993·Biochemical and Biophysical Research Communications·Y J ZhangI B Weinstein
Aug 23, 1996·The Journal of Biological Chemistry·J N LavoieJ Pouysségur
Apr 1, 1997·The Journal of Clinical Investigation·V S SivaramanC C Malbon
Jul 9, 1997·Biochemical and Biophysical Research Communications·C M SchmidtJ V Sitzmann

❮ Previous
Next ❯

Citations

Feb 9, 2007·Journal of Gastroenterology·Yutaka Sasaki
Apr 18, 2013·Environmental Science and Pollution Research International·Rui ZhangXiaowei Zhang
Oct 31, 2008·Advances in Therapy·Patricia Roxburgh, T R Jeffry Evans
Jun 1, 2005·Biochimica Et Biophysica Acta·Tong Wu
Mar 3, 2004·Journal of the American College of Surgeons·Chad A WiesenauerC Max Schmidt
Sep 5, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kjersti JørgensenViví Ann Flørenes
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MasakiM Omata
Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J HayashiO Hino
Sep 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takeya TsutsumiTatsuo Miyamura
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Apr 9, 2008·The Cancer Journal·Melanie B Thomas
Apr 16, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Concha Lopez-GinesMiguel Cerdá-Nicolás
Jan 18, 2011·International Journal of Clinical Practice·R LordP J Ross
Apr 28, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nathalie MajeauDenis Leclerc
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melanie B ThomasAlan Venook
Apr 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bert H O'NeilDaniel M Sullivan
Feb 1, 2008·Annals of Surgical Oncology·Melanie B ThomasPhilip Johnson
May 24, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M IontaG M Machado-Santelli
Apr 6, 2006·Internal Medicine·Kiwamu Okita
Oct 19, 2013·International Journal of Molecular Sciences·Nathalie Zucchini-PascalRoger Rahmani
Mar 29, 2014·International Journal of Molecular Medicine·Osamu NakamuraTetsuji Yamamoto
Oct 15, 2013·Pharmacology & Therapeutics·Cindy NeuzilletEric Raymond
Feb 20, 2009·Journal of Gastroenterology·Melanie Thomas
Jun 23, 2010·Journal of Gastroenterology·Ying-Chun ShenAnn-Lii Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Liver International : Official Journal of the International Association for the Study of the Liver
Yasunori TsuboiYutaka Aoyagi
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
I H McKillopJ V Sitzmann
Biochemical and Biophysical Research Communications
C M SchmidtJ V Sitzmann
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
I H McKillopJ V Sitzmann
© 2022 Meta ULC. All rights reserved