Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths

Toxicological Sciences : an Official Journal of the Society of Toxicology
Cynthia J WolfBarbara D Abbott

Abstract

Perfluoroalkyl acids (PFAAs) are surfactants used in consumer products and persist in the environment. Some PFAAs elicit adverse effects on rodent development and survival. PFAAs can activate peroxisome proliferator-activated receptor alpha (PPARalpha) and may act via PPARalpha to produce some of their effects. This study evaluated the ability of numerous PFAAs to induce mouse and human PPARalpha activity in a transiently transfected COS-1 cell assay. COS-1 cells were transfected with either a mouse or human PPARalpha receptor-luciferase reporter plasmid. After 24 h, cells were exposed to either negative controls (water or dimethyl sulfoxide, 0.1%); positive control (WY-14643, PPARalpha agonist); perfluorooctanoic acid or perfluorononanoic acid at 0.5-100 microM; perfluorobutanoic acid, perfluorohexanoic acid, perfluorohexane sulfonate, or perfluorodecanoic acid (PFDA) at 5-100 microM; or perfluorobutane sulfonate or perfluorooctane sulfonate at 1-250 microM. After 24 h of exposure, luciferase activity from the plasmid was measured. Each PFAA activated both mouse and human PPARalpha in a concentration-dependent fashion, except PFDA with human PPARalpha. Activation of PPARalpha by PFAA carboxylates was positively correlated with...Continue Reading

References

Dec 3, 1999·Toxicology and Applied Pharmacology·E K Maloney, D J Waxman
Nov 25, 2000·Clinical and Experimental Immunology·Q YangJ W Depierre
Feb 27, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·L B BiegelJ C Cook
May 12, 2001·Environmental Science & Technology·J P Giesy, K Kannan
May 12, 2001·Environmental Science & Technology·R Renner
May 17, 2001·International Journal of Toxicology·M T CaseM S Christian
May 8, 2002·Environmental Science & Technology·K J HansenL A Dick
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Andrew M SeacatJohn L Butenhoff
Dec 31, 2002·Toxicology·Andrew M SeacatJohn L Butenhoff
Apr 2, 2003·Environmental Science & Technology·Geary W OlsenJeffrey H Mandel
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauLisa A Stevenson
May 30, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Julie R ThibodeauxChristopher Lau
Jun 14, 2003·TheScientificWorldJournal·J P GiesyP D Jones
Jan 20, 2004·Critical Reviews in Toxicology·James E KlaunigPenelope A Fenner-Crisp
Jan 28, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Rayetta C GrastyJohn M Rogers
Apr 9, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jonathan M ShipleyDavid J Waxman
May 12, 2004·Regulatory Toxicology and Pharmacology : RTP·John L ButenhoffLarry R Zobel
Aug 7, 2004·Environmental Science & Technology·Zsuzsanna KuklenyikAntonia M Calafat
Aug 18, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Moses T BilityJeffrey M Peters
Sep 9, 2004·Environmental Science & Technology·M K SoPaul K S Lam
Oct 6, 2004·Environmental Science & Technology·Kurunthachalam KannanKenneth M Aldoust
Aug 30, 2005·Environmental Science & Technology·Bryan BoulangerKeri C Hornbuckle
Oct 11, 2005·Chemosphere·Antonia M CalafatLuke P Naeher
Dec 3, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Marjorie A PerazaJeffrey M Peters
Jan 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christopher LauMark J Strynar
May 25, 2006·Environmental Science & Technology·Amila O De Silva, Scott A Mabury
Aug 12, 2006·Journal of Occupational and Environmental Medicine·Edward Anthony EmmettLeslie Michael Shaw
Oct 19, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Margy L Takacs, Barbara D Abbott
Nov 14, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Cynthia J WolfBarbara D Abbott
Nov 30, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sally S WhiteSuzanne E Fenton

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Citations

Mar 24, 2012·Environmental Science and Pollution Research International·Marcus NordénMagnus Engwall
Jul 26, 2012·Environmental Science and Pollution Research International·N JacquetP Vasseur
Mar 30, 2013·Environmental Science and Pollution Research International·Manhai LongEva Cecilie Bonefeld-Jørgensen
Mar 12, 2011·Journal of Agricultural and Food Chemistry·Pengfei QinYue Teng
Sep 15, 2011·Chemical Research in Toxicology·Jeffrey M Peters, Frank J Gonzalez
Apr 11, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer E ForemanJeffrey M Peters
May 2, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·James A Bjork, Kendall B Wallace
Jun 30, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mitchell B RosenJ Christopher Corton
Jul 21, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nathan J HickeySean W Kennedy
Aug 11, 2012·PloS One·Mei-Huei ChenWu-Shiun Hsieh
Feb 26, 2010·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Sierra Rayne, Kaya Forest
Feb 4, 2014·Environment International·Emiko OkadaReiko Kishi
Jan 1, 2010·PPAR Research·Christopher LauMichael L Cunningham
Feb 2, 2015·The Science of the Total Environment·Xiao-Wen ZengGuang-Hui Dong
Nov 11, 2011·Chemosphere·Jonathan E NaileJohn P Giesy
Aug 23, 2011·Reproductive Toxicology·Maria SundströmJohn L Butenhoff
May 12, 2009·Reproductive Toxicology·Christopher LauJennifer Seed
Oct 4, 2015·Environmental Research·Margret SkuladottirThorhallur I Halldorsson
Jun 5, 2015·Journal of Environmental Sciences (China)·Hui LiuJiayin Dai
Apr 22, 2015·Aquatic Toxicology·Mazhar UlhaqStefan Örn
Apr 10, 2013·Toxicology·Mitchell B RosenChristopher Lau
Dec 3, 2014·Molecular and Cellular Endocrinology·Andrew M WatkinsBarbara D Abbott

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