Activation of mTOR signaling pathway contributes to survival of cervical cancer cells

Gynecologic Oncology
Jing Ji, Peng-Sheng Zheng

Abstract

The mammalian target of rapamycin (mTOR) pathway is activated in a range of malignant cancers, but its role in human cervical cancer has not been well defined. This study aims to investigate the activation of mTOR pathway in cervical carcinomas and whether inhibition of mTOR with rapamycin, as well as specific siRNA, could lead to decreased proliferation, induced cell cycle arrest and apoptosis. A cervical cancer tissue microarray was tested for activation of the mTOR pathway. The effects on HeLa cell survival and downstream signaling were determined following mTOR inhibition by increasing doses of rapamycin, or silencing by siRNA. The mTOR pathway is activated in cervical carcinomas. mTOR-specific siRNA effectively suppressed HeLa cell growth through mechanisms including inhibition of the cell cycle and increased apoptosis, which were similar to the mechanisms of rapamycin action. The mTOR signaling pathway is activated in cervical carcinomas. Inhibition of mTOR represents a potential therapeutic strategy for cervical cancers.

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Citations

Feb 11, 2011·Oxidative Medicine and Cellular Longevity·Zhao Zhong ChongKenneth Maiese
Apr 17, 2012·Gynecologic Oncology·Flora ZagouriRupert Bartsch
Mar 3, 2012·Cancer Treatment Reviews·Ivan Diaz-PadillaAmit M Oza
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Nov 30, 2016·Oncology Letters·Daniele Xavier AssadEliete Neves Silva Guerra
May 10, 2020·Molecular Biology Reports·Nima HemmatHossein Bannazadeh Baghi
Feb 28, 2013·International Journal of Molecular Sciences·Jiarui LiHui Ning
Apr 2, 2016·Molecular Medicine Reports·Ceren SucularliOzlen Konu
Nov 16, 2019·European Journal of Pharmacology·Michał AntoszczakAdam Huczyński

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