PMID: 11605942Oct 19, 2001Paper

Activation of mu-opioid receptor induces expression of c-fos and junB via mitogen-activated protein kinase cascade

Anesthesiology
T ShodaH Morikawa

Abstract

Opioid-induced long-term functional alterations of the nervous system, such as tolerance, addiction, and dependence, conceivably involve changes in gene expression. The authors have previously reported that opioid receptors are functionally coupled to extracellular signal-regulated kinase, a class of the mitogen-activated protein kinase. To address whether activation of the opioid receptor induces changes in gene expression through the activation of extracellular signal-regulated kinase, the authors examined mu-opioid receptor (MOR)-induced immediate early gene expression. Chinese hamster ovary cells stably expressing MOR were used. Cells were stimulated by MOR agonists after 24-h serum starvation. Expression of c-fos and junB genes was analyzed by RNA blot hybridization. To explore the mechanism of MOR-mediated c-fos and junB expression, activity of a transcription factor, Elk-1, was assessed by reporter assay. Furthermore, to investigate the functional consequences of c-fos and junB induction, MOR-mediated formation of the functional transcription factor complex AP-1 was examined by reporter assay and electrophoretic mobility shift assay. Mu-opioid receptor activation induced c-fos and junB messenger RNAs, which were inhibite...Continue Reading

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Citations

Jul 30, 2002·Anesthesia and Analgesia·Kazuhiko FukudaHisatoshi Uga
Jan 25, 2016·Reproductive Biomedicine Online·Fabian LungerBeata Seeber
Jul 24, 2003·The American Journal of Pathology·Mariko WatanabeRyouichi Horie
Nov 24, 2011·The American Journal of Pathology·Mariko WatanabeRyouichi Horie
Aug 20, 2004·Pharmacological Reviews·Irmgard Tegeder, Gerd Geisslinger
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Prudence H Tso, Yung H Wong
Sep 21, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·David BrinkmanHenry P Redmond
Dec 11, 2019·Neuroscience and Biobehavioral Reviews·Corey B PuryearConnie Sanchez

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