Activation of murine macrophages by Neisseria meningitidis and IFN-gamma in vitro: distinct roles of class A scavenger and Toll-like pattern recognition receptors in selective modulation of surface phenotype

Journal of Leukocyte Biology
Subhankar MukhopadhyaySiamon Gordon

Abstract

Innate and adaptive immune activation of macrophages (Mphi) by microorganisms and antigen-activated lymphoid cells, respectively, plays an important role in host defense and immunopathology. Antigen-presenting cells express a range of pattern recognition receptors including the class A types I and II scavenger receptors (SR-A) and Toll-like receptors (TLR). Recognition of microbial products by SR-A and TLR controls uptake, killing, altered gene expression, and the adaptive immune response; however, the contribution of each receptor and interplay with cytokine stimuli such as interferon-gamma (IFN-gamma) are not defined. We used Neisseria meningitidis (NM), a potent activator of innate immunity, and IFN-gamma, a prototypic T helper cell type 1 proinflammatory cytokine, to compare surface antigens, secretion of mediators, and receptor functions in elicited peritoneal Mphi from wild-type and genetically modified mouse strains. We show that these stimuli regulate major histocompatibility complex type II (MHC-II) and costimulatory molecules differentially, as well as expression of the mannose receptor and of Mphi receptor with collagenous structure (MARCO), a distinct SR-A, which provides a selective marker for innate activation. In...Continue Reading

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Citations

Jan 29, 2008·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Koshiro MiuraMutsunori Shirai
Jan 30, 2008·Free Radical Biology & Medicine·Raymond F HamiltonAndrij Holian
Jun 27, 2009·Immunopharmacology and Immunotoxicology·Hye Young ShinHyun Park
Mar 10, 2006·European Journal of Immunology·Subhankar MukhopadhyaySiamon Gordon
Oct 16, 2004·Immunobiology·Subhankar Mukhopadhyay, Siamon Gordon
Mar 8, 2018·International Journal of Molecular Sciences·Weilin WangLinsheng Song
May 18, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Siamon Gordon
Jan 6, 2009·Immunological Reviews·Dawn M E Bowdish, Siamon Gordon
Apr 25, 2009·Cellular Microbiology·Thomas Areschoug, Siamon Gordon
Feb 18, 2010·European Journal of Immunology·Yunying ChenMikael C I Karlsson
Apr 25, 2013·Journal of Biomedical Materials Research. Part a·Ryan J Love, Kim S Jones
Jun 1, 2007·American Journal of Physiology. Renal Physiology·Daryl M OkamuraAllison A Eddy
Jun 7, 2015·Journal of Leukocyte Biology·Bryan D FlemingDavid M Mosser
Sep 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robin MihrshahiMarion H Brown
Jan 12, 2012·Cellular Microbiology·S HontelezG J Adema
Aug 17, 2019·Frontiers in Cardiovascular Medicine·Sinead A O'RourkeMichael G Monaghan
Jan 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martijn D B van de GardeJörg Hamann
Feb 1, 2019·Advanced Biosystems·Yi WangHao Wang
Nov 17, 2009·Molecular Immunology·Kok-Hooi YewChristopher Harrison
May 16, 2006·Journal of Neuroimmunology·Clive S McKimmieJohn K Fazakerley
Nov 21, 2007·Microbes and Infection·D M E BowdishS Gordon

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