Activation of NADPH-recycling systems in leaves and roots of Arabidopsis thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix hydrolase 19 (AtNUDX19) gene

Journal of Plant Physiology
Francisco J CorpasShigeru Shigeoka

Abstract

NADPH is an important cofactor in cell growth, proliferation and detoxification. Arabidopsis thaliana Nudix hydrolase 19 (AtNUDX19) belongs to a family of proteins defined by the conserved amino-acid sequence GX5-EX7REUXEEXGU which has the capacity to hydrolyze NADPH as a physiological substrate in vivo. Given the importance of NADPH in the cellular redox homeostasis of plants, the present study compares the responses of the main NADPH-recycling systems including NADP-isocitrate dehydrogenase (ICDH), glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH) and NADP-malic enzyme (ME) in the leaves and roots of Arabidopsis wild-type (Wt) and knock-out (KO) AtNUDX19 mutant (Atnudx19) plants under physiological and arsenic-induced stress conditions. Two major features were observed in the behavior of the main NADPH-recycling systems: (i) under optimal conditions in both organs, the levels of these activities were higher in nudx19 mutants than in Wt plants; and, (ii) under 500μM AsV conditions, these activities increase, especially in nudx19 mutant plants. Moreover, G6PDH activity in roots was the most affected enzyme in both Wt and nudx19 mutant plants, with a 4.6-fold and 5.0-fold increase, respectively....Continue Reading

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Citations

Aug 5, 2017·Journal of Cell Science·Francisco J Corpas, Juan B Barroso
Jul 30, 2017·The Protein Journal·Salama R AbdelraheimAlexander G McLennan
Feb 18, 2020·Journal of Experimental Botany·Valentin ChaputLaurence Lejay
Oct 3, 2020·BMC Plant Biology·Raheleh Mirdar MansuriParisa Daryani
Jun 4, 2019·Physiologia Plantarum·María A Muñoz-VargasFrancisco J Corpas
Sep 19, 2020·Journal of Experimental Botany·Francisco J CorpasJosé M Palma
Nov 7, 2020·Journal of Hazardous Materials·Javaid Akhter BhatFrancisco J Corpas

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