Activation of natural killer cells: underlying molecular mechanisms revealed

Scandinavian Journal of Immunology
E BackströmH-G Ljunggren

Abstract

Natural killer (NK) cells, the third major lymphocyte population, are important effector cells against certain infections and tumours. They have also been implicated as a link between innate and adaptive immune responses. In recent years, much attention has been paid to the NK cell inhibitory receptors and their interaction with major histocompatibility complex class I molecules on target cells. This review summarizes recent findings on regulation of NK cell activity with an emphasis on NK cell stimulatory receptors. A particular emphasis is devoted to the receptor NKG2D that is expressed on all NK cells.

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Citations

Dec 13, 2006·Clinical & Developmental Immunology·Melanie RodackiJosé Egídio Paulo de Oliveira
Jul 6, 2014·International Immunopharmacology·Leszek Szablewski
Aug 28, 2009·Veterinary Immunology and Immunopathology·Yi-Chun LinRea-Min Chu
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Mar 15, 2018·International Journal of Molecular Sciences·Valeria La MarcaAlessandra Fierabracci

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