Activation of neuropeptide S-expressing neurons in the locus coeruleus by corticotropin-releasing factor.

The Journal of Physiology
Kay JünglingHans-Christian Pape

Abstract

A recently discovered neurotransmitter system, consisting of neuropeptide S (NPS), NPS receptor, and NPS-expressing neurons in the brain stem, has received considerable interest due to its modulating influence on arousal, anxiety and stress responsiveness. Comparatively little is known about the properties of NPS-expressing neurons. Therefore in the present study, a transgenic mouse line expressing enhanced green fluorescent protein (EGFP) in NPS neurons was used to characterize the cellular and functional properties of NPS-expressing neurons located close to the locus coeruleus. Particular emphasis was on the influence of corticotropin-releasing factor (CRF), given previous evidence of stress-related activation of the NPS system. Upon acute immobilization stress, an increase in c-fos expression was detected immunocytochemically in brain stem NPS-EGFP neurons that also expressed the CRF receptor 1 (CRF1). NPS-EGFP neurons were readily identified in acute slice preparations and responded to CRF application with a membrane depolarization capable of triggering action potentials. CRF-induced responses displayed pharmacological properties indicative of CRF1 that were mediated by both a reduction in membrane potassium conductance and...Continue Reading

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Citations

Jun 12, 2014·Virchows Archiv : an International Journal of Pathology·V PulkkinenJ Arola
Oct 16, 2015·Brain Structure & Function·Csaba AdoriTomas Hökfelt
May 6, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kay JünglingHans-Christian Pape
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Aug 10, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Cesar R Romero-Leguizamón, Kristi A Kohlmeier
Apr 4, 2021·Pharmaceuticals·Luca BotticelliMaria Vittoria Micioni Di Bonaventura

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