Activation of neurotensin receptors in the prefrontal cortex stimulates midbrain dopamine cell firing

European Journal of Pharmacology
P P RompréJ Moisan

Abstract

The effects of medial prefrontal cortex microinjections of 3 nmol/0.5 microl of neurotensin-(1-13), the inactive fragment neurotensin-(1-8), or vehicle on the firing rate of midbrain dopamine neurons were studied in anesthetized rats. Twelve of 19 cells tested with neurotensin-(1-13) showed an average 20-25% increase in firing rate between 10 and 20 min after the injection. This effect was not mimicked by neurotensin-(1-8) (9 cells), nor by a control injection (10 cells) suggesting that it is mediated by high-affinity neurotensin receptors. These results suggest that activation of neurotensin receptors in the medial prefrontal cortex can modulate neural activity of a subpopulation of midbrain dopamine neurons.

References

Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D HerveW Rostene

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Citations

Jun 2, 2005·Regulatory Peptides·María G López Ordieres, Georgina Rodríguez de Lores Arnaiz
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke
Mar 16, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Klara FelszeghyDidier Pélaprat
May 11, 2005·Expert Opinion on Investigational Drugs·Mona BoulesElliott Richelson
Sep 9, 2004·Brain Research·Elena H ChartoffDaniel M Dorsa
Jan 13, 2016·Journal of Psychopharmacology·Luca FerraroMalgorzata Filip
Dec 18, 2019·Biochimica Et Biophysica Acta. Biomembranes·Juan Francisco Bada JuarezAnthony Watts

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