Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment

Molecular Metabolism
Andrea A HillAlyssa H Hasty

Abstract

Macrophage accumulation in adipose tissue (AT) during obesity contributes to inflammation and insulin resistance. Recruitment of monocytes to obese AT has been the most studied mechanism explaining this accumulation. However, recent evidence suggests that recruitment-independent mechanisms may also regulate pro-inflammatory AT macrophage (ATM) numbers. The role of increased ATM survival during obesity has yet to be explored. We demonstrate that activation of apoptotic pathways is significantly reduced in ATMs from diet-induced and genetically obese mice. Concurrently, pro-survival Bcl-2 family member protein levels and localization to the mitochondria is elevated in ATMs from obese mice. This increased pro-survival signaling was associated with elevated activation of the transcription factor, NF-κB, and increased expression of its pro-survival target genes. Finally, an obesogenic milieu increased ATM viability only when NF-κB signaling pathways were functional. Our data demonstrate that obesity promotes survival of inflammatory ATMs, possibly through an NF-κB-regulated mechanism.

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Citations

Apr 2, 2016·Oxidative Medicine and Cellular Longevity·K S Petersen, C Smith
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Jun 5, 2019·Proceedings of the National Academy of Sciences of the United States of America·Injae HwangJae Bum Kim
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Sep 17, 2020·Immunity·Aileen H Lee, Vishwa Deep Dixit

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Methods Mentioned

BETA
nuclear translocation
nuclear magnetic resonance
FACS
confocal microscopy
imaging technique

Software Mentioned

ImageJ64
Image Xpress Automated
Meta Xpress
GraphPad Prism
Image Studio Lite
Image Xpress

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