PMID: 9535136Apr 16, 1998Paper

Activation of non-NMDA receptors stimulates acetylcholine and GABA release from dorsal hippocampus: a microdialysis study in the rat

Neuroscience Letters
M G GiovanniniG Pepeu

Abstract

The effect of the non-N-methyl-D-aspartate (NMDA) agonists (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and quisqualate (QUIS) on the release of acetylcholine (ACh), gamma-amino butyric acid (GABA), aspartate (Asp) and glutamate (Glu) from the hippocampus of freely moving rats was studied by transversal microdialysis. Intracerebroventricular (i.c.v.) administration of the non-NMDA receptor agonist AMPA (0.5 nmol) enhanced (by about 200%) ACh release from the hippocampus. The effect of AMPA was completely antagonized by 6-nitro-7-sulphamoyl-benz(f)quinoxaline-2,3-dione (NBQX; 2 nmol, i.c.v). No effect was seen when AMPA was perfused through the septum. However, AMPA (200 microM) locally applied to the hippocampus, increased (by about 200%) ACh release. QUIS (200 microM) applied locally to the hippocampus produced a long-lasting increase in the release of ACh (by about 215%) and GABA (by about 460%). Local infusion of tetrodotoxin (1 microM) decreased ACh and GABA basal extracellular levels, and abolished the QUIS-induced increase in ACh and GABA. Our results demonstrate that non-NMDA glutamatergic receptors in the hippocampus regulate hippocampal release of GABA and ACh.

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Citations

Oct 8, 1999·European Journal of Pharmacology·K Nakamura, M Shirane
May 14, 2003·Neurochemistry International·Pirjo Saransaari, Simo S Oja
Jan 1, 1997·Epilepsy Research·C E StafstromG L Holmes
Jun 16, 2004·Neuroscience Letters·Cornelia KiewertJochen Klein
Dec 20, 2005·Neurochemical Research·Pirjo Saransaari, Simo S Oja
Oct 18, 2007·Neurochemical Research·Pirjo Saransaari, Simo S Oja

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