Activation of Nrf2/HO-1 Pathway by Nardochinoid C Inhibits Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages

Frontiers in Pharmacology
Jin-Fang LuoHua Zhou

Abstract

The roots and rhizomes of Nardostachys chinensis have neuroprotection and cardiovascular protection effects. However, the specific mechanism of N. chinensis is not yet clear. Nardochinoid C (DC) is a new compound with new skeleton isolated from N. chinensis and this study for the first time explored the anti-inflammatory and anti-oxidant effect of DC. The results showed that DC significantly reduced the release of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)-activated RAW264.7 cells. The expression of pro-inflammatory proteins including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were also obviously inhibited by DC in LPS-activated RAW264.7 cells. Besides, the production of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were also remarkably inhibited by DC in LPS-activated RAW264.7 cells. DC also suppressed inflammation indicators including COX-2, PGE2, TNF-α, and IL-6 in LPS-stimulated THP-1 macrophages. Furthermore, DC inhibited the macrophage M1 phenotype and the production of reactive oxygen species (ROS) in LPS-activated RAW264.7 cells. Mechanism studies showed that DC mainly activated nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, increa...Continue Reading

References

Jan 1, 1995·Annual Review of Pharmacology and Toxicology·D L Laskin, K J Pendino
May 23, 1998·Annual Review of Immunology·S GhoshE B Kopp
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Oct 6, 2001·Journal of Clinical Gastroenterology·A L Buchman
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jed W FaheyAlain Lozniewski
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Aug 2, 2003·International Immunopharmacology·Soichi NoguchiTakafumi Kudo
Oct 23, 2003·Nature Reviews. Cancer·Young-Joon Surh
Jan 6, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·MacRae F Linton, Sergio Fazio
Sep 29, 2004·Biochemical Pharmacology·Klaokwan Srisook, Young-Nam Cha
May 19, 2005·Arthritis Research & Therapy·Annaleise V SampeyLeslie J Crofford
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Nagatoshi Fujiwara, Kazuo Kobayashi
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·T SatohS A Lipton
Apr 8, 2006·Physiological Reviews·Stefan W RyterAugustine M K Choi
Oct 3, 2006·Cardiovascular Research·Annika LindeTonatiuh Melgarejo
Nov 14, 2006·Biochemical and Biophysical Research Communications·Rajesh K ThimmulappaShyam Biswal
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yeon-Joo KangWilliam L Smith
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Feb 1, 1991·Planta medica·A BagchiH Hikino
Feb 24, 2007·Nature Reviews. Immunology·Yusen LiuLeif D Nelin
Apr 7, 2007·Current Opinion in Rheumatology·Zoltán Szekanecz, Alisa E Koch
Dec 7, 2007·The Journal of Clinical Investigation·Su Wol ChungMark A Perrella
Jul 16, 2008·International Immunopharmacology·Eun Myoung ShinYeong Shik Kim
Oct 18, 2008·Nature Reviews. Immunology·Sankar Ghosh, Matthew S Hayden
Jun 18, 2009·Expert Opinion on Therapeutic Targets·Jinqing LiTaixing Cui
Jan 29, 2010·Immune Network·Hyun-Ock Pae, Hun-Taeg Chung
Oct 11, 2011·Nature Reviews. Immunology·Ajay ChawlaY P Sharon Goh
Nov 15, 2011·Bioorganic & Medicinal Chemistry Letters·Ji Sang HwangBang Yeon Hwang
Dec 14, 2011·The New England Journal of Medicine·Iain B McInnes, Georg Schett
Jan 3, 2012·Seminars in Cancer Biology·Frances R Balkwill, Alberto Mantovani
Feb 2, 2012·Nature Reviews. Drug Discovery·Sarah Crunkhorn
Mar 23, 2012·Immunological Reviews·Joseph A DiDonatoMichael Karin
Jun 30, 2012·Recent Patents on CNS Drug Discovery·Gururaj Joshi, Jeffrey A Johnson
Jul 20, 2012·Nature Reviews. Cancer·Michael B Sporn, Karen T Liby
Jul 27, 2012·Frontiers in Pharmacology·Jesus A AraujoFen Yin

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Citations

Dec 29, 2019·British Journal of Pharmacology·Chengyu YinBoyi Liu
Feb 6, 2020·Marine Drugs·Marcelino GutiérrezElena Talero
Feb 20, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nivedita BanerjeeM Firoze Khan
May 18, 2019·Oxidative Medicine and Cellular Longevity·Emiliano Panieri, Luciano Saso
Jul 10, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yun-Da YaoHua Zhou
May 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Norwin KubickMichel-Edwar Mickael
Nov 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sarmistha SahaLuciano Saso
Feb 23, 2021·Oxidative Medicine and Cellular Longevity·Benjawan DunkhunthodGriangsak Eumkeb
Apr 17, 2021·Pharmacological Reports : PR·Lovedeep SinghRajbir Bhatti
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiaohua WuShugeng Cao
Jun 18, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ge LuMei-Hong Shen
Aug 8, 2021·International Journal of Molecular Sciences·Xiaoxuan ChenYiqun Deng
Sep 12, 2019·Journal of Agricultural and Food Chemistry·Yuanyuan LiLiya Li
Aug 28, 2021·Cells·Don A DaviesBenedict C Albensi
Oct 3, 2021·Environmental Science and Pollution Research International·Ali S AlshehriHeba S Khalifa

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Methods Mentioned

BETA
ELISA
PMA
PCR
Assay
flow cytometry
nuclear translocation
nuclear
transfection

Software Mentioned

GraphPad Prism7

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