Activation of Nrf2/Keap1 signaling and autophagy induction against oxidative stress in heart in iron deficiency

Bioscience, Biotechnology, and Biochemistry
Hirofumi InoueMariko Uehara

Abstract

We investigated the effects of dietary iron deficiency on the redox system in the heart. Dietary iron deficiency increased heart weight and accumulation of carbonylated proteins. However, expression levels of heme oxygenase-1 and LC3-II, an antioxidant enzyme and an autophagic marker, respectively, in iron-deficient mice were upregulated compared to the control group, resulting in a surrogate phenomenon against oxidative stress.

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Citations

Jan 15, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sumit SahniDes R Richardson
Mar 2, 2018·Bioscience, Biotechnology, and Biochemistry·Hirofumi InoueMariko Uehara
Jul 12, 2017·Free Radical Research·Aaron J DoneTinna Traustadóttir
Dec 12, 2017·Biomedical Research·Hirofumi InoueMariko Uehara
Jan 29, 2021·The Biochemical Journal·Sandra Montella-ManuelMaria Angeles de la Torre-Ruiz
May 17, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Allison L Fisher, Jodie L Babitt
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger

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Methods Mentioned

BETA
PCR
nuclear translocation

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