Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation.

Molecular and Cellular Biology
P SchwengerJ Vilcek

Abstract

Many actions of the proinflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) on gene expression are mediated by the transcription factor NF-kappaB. Activation of NF-kappaB by TNF and IL-1 is initiated by the phosphorylation of the inhibitory subunit, IkappaB, which targets IkappaB for degradation and leads to the release of active NF-kappaB. The nonsteroidal anti-inflammatory drug sodium salicylate (NaSal) interferes with TNF-induced NF-kappaB activation by inhibiting phosphorylation and subsequent degradation of the IkappaB alpha protein. Recent evidence indicated that NaSal activates the p38 mitogen-activated protein kinase (MAPK), raising the possibility that inhibition of NF-kappaB activation by NaSal is mediated by p38 MAPK. We now show that inhibition of TNF-induced IkappaB alpha phosphorylation and degradation by NaSal is prevented by treatment of cells with SB203580, a highly specific p38 MAPK inhibitor. Both p38 activation and inhibition of TNF-induced IkappaB alpha degradation were seen after only 30 s to 1 min of NaSal treatment. Induction of p38 MAPK activation and inhibition of TNF-induced IkappaB alpha degradation were demonstrated with pharmacologically achievable doses of NaSal. These findi...Continue Reading

References

Jan 1, 1991·Scientific American·G Weissmann
Jan 1, 1989·Arthritis and Rheumatism·S B Abramson, G Weissmann
Nov 24, 1995·Science·Z XiaM E Greenberg
Oct 13, 1995·The Journal of Biological Chemistry·F BertrandG Cherqui
Mar 1, 1995·Trends in Biochemical Sciences·E Cano, L C Mahadevan
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·S MiyamotoI M Verma
Aug 12, 1994·Science·E Kopp, S Ghosh
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·S C SunW C Greene
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A MitchellJ R Vane
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·C LechnerA Ullrich
May 1, 1996·Southern Medical Journal·N ChalasaniR L Jurado
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Nov 1, 1996·Science·D J Van AntwerpI M Verma
Aug 1, 1996·Cytokine & Growth Factor Reviews·P Beauparlant, J Hiscott
Nov 12, 1996·Biochemical and Biophysical Research Communications·Z LiJ Han
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·J D GravesE A Clark
Apr 1, 1997·Current Opinion in Cell Biology·M J Robinson, M H Cobb
May 1, 1997·Molecular and Cellular Biology·A J WhitmarshR J Davis
May 2, 1997·The Journal of Biological Chemistry·P R YoungJ C Lee
Jul 25, 1997·Cell·C H RégnierM Rothe

❮ Previous
Next ❯

Citations

Mar 19, 1999·Journal of Cellular Physiology·P SchwengerJ Vilcek
Jul 6, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E Martín-Blanco
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A G Bowie, L A O'Neill
Jan 11, 2001·The American Journal of Gastroenterology·H BantelK Schulze-Osthoff
Feb 21, 2002·Journal of the National Cancer Institute·Michael J ThunCarlo Patrono
Oct 31, 2002·The Journal of Biological Chemistry·Defeng Wu, Arthur I Cederbaum
Oct 9, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anna PlanagumàJoan Clària
Mar 5, 2003·Pharmacological Reviews·Jan H von der ThüsenErik A L Biessen
Sep 10, 2003·Journal of Leukocyte Biology·Nina C WeberAlexandra K Kiemer
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael H PillingerSteven B Abramson
Nov 17, 2004·Journal of Cellular Biochemistry·Hyung-Chahn LeeSeok-Il Hong
Jan 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mathieu DerouetSteven W Edwards
Sep 11, 2014·World Journal of Gastroenterology : WJG·Mariabeatrice PrincipiAlfredo Di Leo
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B van den BlinkM P Peppelenbosch
Jan 25, 2002·Journal of Cellular Physiology·Ja-Young KimSu-Jae Lee
Feb 28, 2002·British Journal of Pharmacology·David J MacEwan
Apr 16, 2005·Molecular Nutrition & Food Research·Catalina Alarcón de la Lastra, Isabel Villegas
Oct 17, 2009·The Journal of Antibiotics·Takao Kataoka
Aug 29, 2014·Geriatrics & Gerontology International·Bokyung SungHae Young Chung
Aug 19, 2016·Experimental & Molecular Medicine·Su-Kang KongIl Yup Chung
Aug 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M SilvaL F Reis
Sep 5, 2001·Molecular and Cellular Biology·O ZugastiU Hibner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.