PMID: 9178950Jun 1, 1997Paper

Activation of p42 mitogen-activated protein kinase by glutamate in cultured radial glia

Neurochemical Research
A M López-Colomé, A Ortega

Abstract

The effect of L-glutamate (Glu) and its structural analogs N-methyl-D-aspartate (NMDA), kainate (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), on the activation of p42 mitogen activated protein kinase (MAPK) was examined in cultured chick radial glia cells, namely retinal Muller cells and cerebellar Bergmann cells. Glu, NMDA, AMPA and KA evoked a dose and time dependent increase in MAPK activity. AMPA and KA responses were blocked by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) whereas NMDA responses were sensitive to 3-[(RS)-2-carboxypiperazin-4-yl)]-propyl-1-phosphonate (CPP) indicating that the increase in MAPK activity is mediated by AMPA/low affinity KA and NMDA subtypes of Glu receptors. The present findings open the possibility of a MAPK cascade involvement in the regulation of Glu-induced gene expression in radial glia.

Citations

Sep 19, 2002·Journal of Neuroscience Research·Adán AguirreArturo Ortega
Mar 28, 2016·Neurochemical Research·Ana María López-ColoméArturo Ortega
Feb 15, 2008·Neurochemical Research·Ricardo Augusto de Melo ReisFernando Garcia de Mello
Dec 18, 2001·Journal of Neuroscience Research·A MillánA Ortega
Dec 20, 2005·Neurochemical Research·Edith LópezAna María López-Colomé
Jun 22, 2006·Journal of Neurochemistry·Esther López-BayghenArturo Ortega
Dec 28, 2018·Journal of Neurochemistry·Rebeca Rosas-HernándezJ Alfredo Mendez
Nov 21, 2007·Journal of Cellular Biochemistry·Sofía GarcíaAna María López-Colomé
Aug 1, 1998·Brain Research. Molecular Brain Research·T LópezA Ortega

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