PMID: 8985881Dec 1, 1996Paper

Activation of pharmacologically distinct metabotropic glutamate receptors depresses reticulospinal-evoked monosynaptic EPSPs in the lamprey spinal cord

Journal of Neurophysiology
P KriegerS Grillner

Abstract

1. Different metabotropic glutamate receptors (mGluRs) can modulate synaptic transmission in different regions in the CNS, but their roles at individual synaptic connections have not been detailed. We used paired intracellular recordings from reticulospinal axons and their postsynaptic target neurons in the lamprey spinal cord to investigate the effects of mGluR activation on glutamatergic synaptic transmission. 2. The mGluR agonists (1S,3R)-1-aminocyclopentane-1,3-dicarboxyylic acid [(1S,3R)-ACPD] and L(+)-2-amino-4-phosphonobutyric acid (L-AP4) both reduced the amplitude of monosynaptic excitatory postsynaptic potentials (EPSPs) elicited by stimulation of single reticulospinal axons. The depression of monosynaptic unitary EPSPs occurred without any apparent change in the input resistance of postsynaptic neurons. Furthermore, the mGluR agonists did not affect the amplitude of (RS)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-induced depolarizations. Taken together, these results thus suggest that (1S,3R)-ACPD and L-AP4 depress reticulospinal synaptic transmission via presynaptic mechanisms. 3. (2S,1'S,2'S)-2-(carboxycyclopropyl) glycine (L-CCG-I), which selectively activates group II mGluRs, also reduced the...Continue Reading

Citations

Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Abdeljabbar El Manira, Peter Wallén
Apr 10, 2003·British Journal of Pharmacology·Ali Shahraki, Trevor W Stone
Sep 27, 2007·The European Journal of Neuroscience·Rebecca J Chapman, Keith T Sillar
Nov 6, 2009·Journal of Neurophysiology·Evanthia Nanou, Abdeljabbar El Manira
Feb 3, 1999·Annals of the New York Academy of Sciences·S GrillnerA el Manira
Jun 20, 2003·Journal of Neurophysiology·Petronella KettunenAbdeljabbar El Manira
Aug 24, 2002·The European Journal of Neuroscience·Fulvia BongianniTito Pantaleo
Apr 7, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Simon AlfordGonzalo Viana di Prisco
Apr 14, 1999·Journal of Neurophysiology·P KriegerA el Manira
Jun 14, 2008·Journal of Neurophysiology·Katharina A Quinlan, James T Buchanan
Jan 12, 2001·Journal of Neurophysiology·F AokiS Grillner
Aug 21, 2020·The Journal of Experimental Biology·Gabriel F ColtonMichael P Nusbaum
Jul 4, 1998·Brain Research. Brain Research Reviews·S GrillnerP Wallén
Jul 19, 2002·The Journal of Comparative Neurology·Jenny S GustafssonOleg Shupliakov

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