Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes.

The Journal of Biological Chemistry
H OhK Yamauchi-Takihara

Abstract

Phosphatidylinositol (PI) 3-kinase is known to be activated by cytokine stimulation through different types of receptors to transduce intracellular responses. We have previously reported that leukemia inhibitory factor (LIF) induces the activation of Janus kinase signal transducer and activator of transcription (JAK-STAT) and mitogen-activated protein (MAP) kinase pathways through glycoprotein (gp) 130 in cardiac myocytes. However, whether PI 3-kinase is involved in regulation of gp130 signaling and the activation mechanisms by which it associates with other tyrosine-phosphorylated proteins remain unknown. We found that LIF induced the activation of PI 3-kinase in cardiac myocytes. Moreover, JAK1 binds to PI 3-kinase, and LIF stimulation increases the PI 3-kinase activity in JAK1 immunoprecipitates. Activation of MAP kinase and protein kinase B by LIF was attenuated by wortmannin. LIF-induced p70 S6 kinase activation, protein synthesis, and c-fos mRNA expression were inhibited by wortmannin and rapamycin. Both inhibitors failed to appreciably affect the phosphorylation of STAT3. In conclusion, PI 3-kinase is activated with LIF in cardiac myocytes, and JAK1 is found to associate with this enzyme. PI 3-kinase provides a crucial l...Continue Reading

References

Jan 25, 1991·Cell·L C CantleyS Soltoff
Mar 10, 1995·The Journal of Biological Chemistry·E Giasson, S Meloche
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·H HirotaT Taga
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·Q P WengJ Avruch
Mar 1, 1995·Circulation·K Yamauchi-TakiharaT Kishimoto
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M NarazakiT Taga
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·K YoshidaT Kishimoto
Apr 12, 1996·The Journal of Biological Chemistry·M WilsonN G Anderson
Aug 16, 1996·The Journal of Biological Chemistry·T TsakiridisA Klip
Feb 21, 1997·The Journal of Biological Chemistry·O RobledoH Gascan
Feb 21, 1997·Cell·T F FrankeL C Cantley
May 30, 1997·The Journal of Biological Chemistry·K ReifD A Cantrell
Jun 15, 1997·The Journal of Clinical Investigation·Y FujioT Kishimoto
Jun 9, 1997·FEBS Letters·C L SableE Van Obberghen

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Citations

May 29, 2007·Basic Research in Cardiology·P Fischer, D Hilfiker-Kleiner
Oct 6, 2007·Basic Research in Cardiology·Philipp Fischer, Denise Hilfiker-Kleiner
Mar 23, 2005·Current Opinion in Pharmacology·Michael R Morissette, Anthony Rosenzweig
Jul 2, 2003·Brain, Behavior, and Immunity·Andreas JeronFrank Muders
May 10, 2001·Trends in Cardiovascular Medicine·K Yamauchi-Takihara, T Kishimoto
Mar 16, 2000·International Journal of Experimental Pathology·K Yamauchi-Takihara, T Kishimoto
Aug 2, 2003·Clinical and Experimental Pharmacology & Physiology·R D HannanY Brandenburger
Jun 20, 2008·The Journal of Biological Chemistry·Ursula A WhiteJacqueline M Stephens
Aug 12, 2010·Antioxidants & Redox Signaling·Gabriela M KusterOtmar Pfister
Oct 14, 2004·Bioinformatics·Peter J WoolfDouglas A Lauffenburger
Aug 2, 2000·The EMBO Journal·I GoutV L Buchman
May 19, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Espen E Spangenburg
Feb 22, 2001·Annual Review of Physiology·J D Molkentin, G W Dorn
Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mazen Kurdi, George W Booz
Jun 10, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Hongguang Wei, Richard S Vander Heide
Aug 19, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Michael D GoodmanKaryn L Butler
Jul 12, 2011·Physiological Reviews·Mark A SussmanMichael McGregor
Jan 17, 2013·The Journal of Clinical Investigation·Stefan ThiemMatthias Ernst
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sachiko MuraseRonald D McKay
Jul 1, 2008·Future Cardiology·Keiko Yamauchi-Takihara
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·H OhM D Schneider
Sep 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Gianluigi CondorelliJohn Ross
Jul 9, 2013·Experimental and Molecular Pathology·Silke KuphalAnja K Bosserhoff
Jul 11, 2000·Journal of Molecular and Cellular Cardiology·T UeyamaM Yokoyama
Apr 21, 2010·Heart Failure Reviews·Mona HedayatNima Rezaei
Jan 10, 2016·Molecular Neurobiology·Stephanie M DavisKeith R Pennypacker
Jun 18, 2004·Annals of the New York Academy of Sciences·Michael V G LatronicoGianluigi Condorelli
Feb 5, 2008·British Journal of Pharmacology·P Fischer, D Hilfiker-Kleiner

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