PMID: 45272Nov 1, 1979

Activation of phosphatidylserine synthesis: a possible mechanism of regulation of the base-exchange enzymic system

The Italian Journal of Biochemistry
E CastigliG Porcellati


The possible relationship between phosphatidyl serine synthesis by base-exchange and nervous activity has been investigated in the rat caudate nucleus. The rate of incorporation of L-serine into the phosphatidyl serine of slices from caudate nucleus is not affected by dopamine nor is it affected by the addition to dopamine of a cyclic phosphodiesterase inhibitor which would increase the endogenous cyclic-AMP levels. However, imidazole, a phosphodiesterase activator, clearly stimulates by more than 100% the phosphatidyl serine synthesis in the slices. The activation is not due to interaction at the catalytic site(s) of the base-exchange system, since it is neither observed in homogenates of caudate nucleus nor in cerebral microsomes at various pH values.

Related Concepts

Phosphodiesterase Inhibitors
Positive Regulation of Phosphatidylserine Biosynthetic Process
Dopamine Measurement
Cyclic AMP, (R)-Isomer

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