Activation of physiological stress responses by a natural reward: Novel vs. repeated sucrose intake

Physiology & Behavior
Ann E Egan, Y M Ulrich-Lai

Abstract

Pharmacological rewards, such as drugs of abuse, evoke physiological stress responses, including increased heart rate and blood pressure, and activation of the hypothalamic-pituitary-adrenal (HPA) axis. It is not clear to what extent the natural reward of palatable foods elicits similar physiological responses. In order to address this question, HPA axis hormones, heart rate, blood pressure and brain pCREB immunolabeling were assessed following novel and repeated sucrose exposure. Briefly, adult, male rats with ad libitum food and water were given either a single (day 1) or repeated (twice-daily for 14 days) brief (up to 30 min) exposure to a second drink bottle containing 4 ml of 30% sucrose drink vs. water (as a control for bottle presentation). Sucrose-fed rats drank more than water-fed on all days of exposure, as expected. On day 1 of exposure, heart rate, blood pressure, plasma corticosterone, and locomotion were markedly increased by presentation of the second drink bottle regardless of drink type. After repeated exposure (day 14), these responses habituated to similar extents regardless of drink type and pCREB immunolabeling in the hypothalamic paraventricular nucleus (PVN) also did not vary with drink type, whereas baso...Continue Reading

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Citations

Mar 16, 2016·Current Opinion in Behavioral Sciences·Yvonne M Ulrich-Lai
Apr 5, 2016·Physiology & Behavior·M L GoodsonKaren K Ryan
Aug 8, 2015·Brain Structure & Function·Yvonne M Ulrich-LaiJames P Herman
Jul 31, 2016·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Jerome Kagan
Jan 8, 2017·Clinical and Experimental Pharmacology & Physiology·Hoda RanjbarHojjatallah Alaei
Jun 10, 2017·Brain Structure & Function·Amy E B PackardYvonne M Ulrich-Lai
Nov 29, 2017·The International Journal of Neuropsychopharmacology·Nicola SimolaMicaela Morelli

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