Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory.

PloS One
Jose A CrespoGerald Zernig

Abstract

One of the greatest challenges in the treatment of substance dependence is to reverse the control that drug-associated stimuli have gained over the addict's behavior, as these drug-associated memories increase the risk of relapse even after long periods of abstinence. We report here that inhibition of the atypical protein kinase C isoform PKCzeta and its constitutively active isoform PKMzeta with the pseudosubstrate inhibitor ZIP administered locally into the nucleus accumbens core reversibly inhibited the retrieval of drug-associated memory and drug (remifentanil) seeking, whereas a scrambled ZIP peptide or staurosporine, an effective inhibitor of c/nPKC-, CaMKII-, and PKA kinases that does not affect PKCzeta/PKMzeta activity, was without effect on these memory processes. Acquisition or extinction of drug-associated memory remained unaffected by PKCzeta- and PKMzeta inhibition.

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Citations

Apr 15, 2014·Journal of Drug and Alcohol Research·María E Vélez-HernándezCarlos A Jiménez-Rivera
Feb 16, 2013·F1000 Biology Reports·David L Glanzman
Sep 19, 2012·Molecular Brain·Todd Charlton Sacktor
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Oct 1, 2013·Brain Research Bulletin·Janine L Kwapis, Fred J Helmstetter
Apr 10, 2020·Neuronal Signaling·Sophie M HapakSourav Ghosh
Feb 9, 2021·Reviews in the Neurosciences·Hamish Patel, Reza Zamani
Sep 23, 2020·Current Opinion in Pharmacology·Uršulė TaujanskaitėAmy L Milton
Jun 17, 2015·Learning & Memory·Sajiya J JalilHarel Z Shouval
Dec 17, 2015·Learning & Memory·Bruna Amanda GirardiMaribel Antonello Rubin

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Methods Mentioned

BETA
antisense oligonucleotides
sedation
protein assay
electrophoresis

Software Mentioned

SPSS®

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