Activation of plasma kinin system correlates with severe coagulation disorders in patients with ovarian hyperstimulation syndrome

Human Reproduction
H KodamaT Tanaka

Abstract

The aim of this study was to evaluate status of plasma kinin system in patients with ovarian hyperstimulation syndrome (OHSS), in order to investigate whether activation of the plasma kinin system correlates with increased blood coagulability. In the first part of the study, concentrations of plasma prekallikrein (PK) in OHSS cycles (n = 13) were monitored from the day of human chorionic gonadotrophin (HCG) administration to the mid-luteal phase, and were compared with those of control cycles (n = 17). The average value of PK in OHSS cycles began to decrease on day 8, and by day 10 was significantly lower than that of control cycles (86 +/- 6 versus 106 +/- 4%, P <0.01). The time course of changes in PK concentration correlated well with the clinical condition of OHSS patients. In the second part of the study, we obtained data from 26 patients who were hospitalized because of severe OHSS, to investigate the correlation between PK and other haemostatic markers. OHSS patients with severe PK reduction (<80% normal, n = 9) demonstrated significantly higher values of plasma thrombin-antithrombin III and plasmin-alpha2 antiplasmin, and more severe haemoconcentration, compared to those OHSS patients who had no reduction in PK (n = 17)...Continue Reading

Citations

Feb 22, 2011·Journal des maladies vasculaires·J ConardA Gompel
Nov 4, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Bilge CelebiogluTarýk A Aksu
Jul 28, 2004·American Journal of Reproductive Immunology : AJRI·Raoul OrvietoBenjamin Fisch
Jul 12, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Miro KasumMarijeta Pekez
Apr 16, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Angela RogolinoRosanna Abbate
Jan 6, 2021·Thrombosis and Haemostasis·Johannes Jakobsen SidelmannCaroline Kistorp

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