Activation of pmar1 controls specification of micromeres in the sea urchin embryo

Developmental Biology
Paola OliveriDavid R McClay

Abstract

pmar1 is a transcription factor in the paired class homeodomain family that was identified and found to be transcribed in micromeres beginning at the fourth cleavage of sea urchin development [Dev. Biol. 246 (2002), 209]. Based on in situ data, molecular perturbation studies, and QPCR data, the recently published gene regulatory network (GRN) model for endomesoderm specification [Science 295 (2002) 1669; Dev. Biol. 246 (2002), 162] places pmar1 early in the micromere specification pathway, and upstream of two important micromere induction signals. The goal of this study was to test these three predictions of the network model. A series of embryo chimeras were produced in which pmar1 activity was perturbed in one cell that was transplanted to control hosts. At the fourth cleavage, micromeres bearing altered pmar1 activity were combined with a normal micromereless host embryo. If beta-catenin signaling is blocked, the micromeres remain unspecified and are unable to signal to the host cells. When such beta-catenin-blocked micromeres also express Pmar1, all observed micromere functions are rescued. The rescue includes expression of the primary mesenchyme cell (PMC) differentiation program, expression and execution of the Delta sign...Continue Reading

References

Oct 1, 1985·Developmental Biology·G M Wessel, D R McClay
Jan 1, 1986·Methods in Cell Biology·D R McClay
Jan 1, 1982·Methods in Cell Biology·D P Kiehart
Apr 1, 1998·Developmental Biology·A Ransick, E H Davidson
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A H WikramanayakeW H Klein
Apr 24, 2001·Methods : a Companion to Methods in Enzymology·G Hauptmann
Mar 2, 2002·Science·Eric H DavidsonHamid Bolouri
May 25, 2002·Developmental Biology·Eric H DavidsonHamid Bolouri
May 25, 2002·Developmental Biology·Paola OliveriEric H Davidson

❮ Previous
Next ❯

Citations

Oct 14, 2004·Development Genes and Evolution·Yukiko NishimuraMasaaki Yamaguchi
Jun 9, 2004·Gene Expression Patterns : GEP·Takuya MinokawaEric H Davidson
Nov 15, 2008·Nature Protocols·Stefan C Materna, Paola Oliveri
Apr 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Paola OliveriEric H Davidson
Apr 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Feng Gao, Eric H Davidson
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Joel Smith, Eric H Davidson
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zheng WeiLynne M Angerer
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Isabelle S PeterEric H Davidson
Feb 13, 2007·Annual Review of Biophysics and Biomolecular Structure·Smadar Ben-Tabou de-Leon, Eric H Davidson
Feb 9, 2007·Development·Shu-Yu Wu, David R McClay
Aug 11, 2011·Development·Lynne M AngererRobert D Burke
Jan 26, 2012·Development·Joseph P Campanale, Amro Hamdoun
Feb 6, 2009·PLoS Biology·Aditya J SethiLynne M Angerer
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Veronica F HinmanEric H Davidson
Mar 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael Levine, Eric H Davidson
Jul 11, 2014·Integrative and Comparative Biology·Deirdre C LyonsDavid R McClay
Apr 21, 2009·The International Journal of Developmental Biology·Isabelle S Peter, Eric H Davidson
Nov 26, 2009·FEBS Letters·Isabelle S Peter, Eric H Davidson
Jan 31, 2016·Developmental Biology·Ellen V Rothenberg
Jul 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Eric M Erkenbrack, Eric H Davidson
Nov 17, 2009·Current Opinion in Genetics & Development·Eric H Davidson
Aug 6, 2014·Journal of Theoretical Biology·Mengyang SunJoshua E S Socolar
Jun 17, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Enhu Li, Eric H Davidson
Mar 17, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Smadar Ben-Tabou de-Leon, Eric H Davidson
May 19, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christine A ByrumAthula H Wikramanayake
Feb 26, 2013·Genesis : the Journal of Genetics and Development·Charles A Ettensohn
Mar 1, 2012·Wiley Interdisciplinary Reviews. Developmental Biology·Deirdre C LyonsDavid R McClay
Feb 20, 2014·Genesis : the Journal of Genetics and Development·Veronica F Hinman, Alys M Cheatle Jarvela
Feb 20, 2014·Genesis : the Journal of Genetics and Development·Daniel C McIntyreDavid R McClay
Dec 14, 2011·Developmental Biology·Jia L SongGary M Wessel
Nov 10, 2009·Developmental Biology·Isabelle S Peter, Eric H Davidson
Jan 24, 2015·Developmental Biology·Nadezda StepichevaJia L Song
Jun 25, 2009·Mechanisms of Development·Atsuko YamazakiMasaaki Yamaguchi
Aug 26, 2004·Developmental Biology·Ochan OtimEric H Davidson
Jun 16, 2004·Developmental Biology·Meredith L Howard, Eric H Davidson
Apr 6, 2004·Developmental Biology·Montserrat Fernandez-SerraMaria I Arnone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Roger Revilla-i-DomingoEric H Davidson
Proceedings of the National Academy of Sciences of the United States of America
Paola OliveriEric H Davidson
© 2022 Meta ULC. All rights reserved