PMID: 7334025Dec 1, 1981Paper

Activation of potassium-dependent H+ efflux from mitochondria by cadmium and phenylarsine oxide

Journal of Bioenergetics and Biomembranes
D R SANADIS Joshi

Abstract

Addition of Cd2+ or phenylarsine oxide (PhAsO) to respiring rat liver mitochondria results first in acidification of the medium (H+ efflux) followed by disappearance of H+ (discharge of the pH gradient or uncoupling). The first phase of H+ efflux is dependent upon the presence of K+ in the medium, and is not seen in the presence of valinomycin, which is consistent with the conclusion that H+ efflux is linked to membrane potential-dependent uptake of K+. These effects are abolished by low levels of 2,3-dimercaptopropanol but potentiated by excess of 2-mercaptoethanol, showing involvement of a dithiol type of group in the response. Mersalyl produces only the H+ efflux, and subsequent addition of Cd2+ of PhAsO produces collapse of the delta pH.

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Citations

Apr 1, 1986·Journal of Bioenergetics and Biomembranes·J J DiwanT Haley
Jan 1, 1985·The Journal of Membrane Biology·J J Diwan
Jul 25, 2009·Journal of Bioenergetics and Biomembranes·Sergey M Korotkov
Oct 2, 2007·Cell Biochemistry and Biophysics·Noemí GarcíaEdmundo Chávez
Jul 17, 1995·Biochimica Et Biophysica Acta·M Zoratti, I Szabò
Nov 25, 2000·The International Journal of Biochemistry & Cell Biology·C ZazuetaF Correa
Feb 1, 1983·Plant Physiology·F C Knowles, A A Benson
Nov 2, 1984·European Journal of Biochemistry·B K RasheedD R Sanadi
Jun 19, 2008·Journal of Biochemical and Molecular Toxicology·Sergey M KorotkovOlga V Yagodina
Jan 1, 1987·Biochimica Et Biophysica Acta·J J Diwan
Jun 29, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·A DibasT Yorio
Aug 1, 1991·Journal of Bioenergetics and Biomembranes·E LenartowiczG F Azzone
Jan 30, 1987·Biochemical and Biophysical Research Communications·B Persson, J Rydström
May 31, 1988·Biochemical and Biophysical Research Communications·J J DiwanD R Sanadi

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