PMID: 9182691Jun 1, 1997Paper

Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

The Biochemical Journal
Q Zhou, G S Salvesen

Abstract

As a model to investigate the mechanism of caspase activation we have analysed the processing of pro-caspase-7 by serine proteases with varied specificities. The caspase-7 zymogen was rapidly activated by granzyme B and more slowly by subtilisin and cathepsin G, generating active enzymes with similar kinetic properties. Significantly, cathepsin G activated the zymogen by cleaving at a Gln-Ala bond, indicating that the canonical cleavage specificity at aspartic acid is not required for activation.

Citations

Jul 10, 1999·The Journal of Biological Chemistry·B B Wolf, D R Green
Mar 20, 1999·The Journal of Biological Chemistry·H R StennickeG S Salvesen
Sep 20, 2000·Leukemia·D E Johnson
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Magali PederzoliVéronique Witko-Sarsat
Dec 18, 2008·Bioorganicheskaia khimiia·A V SintsovM A Khanin
Nov 26, 2009·Nature Reviews. Immunology·Phillip I BirdJosé A Villadangos
Oct 15, 2010·Bioscience Reports·Dave BoucherJean-Bernard Denault
Dec 13, 2017·Scientific Reports·Jin-Yong LeeMasahiko Satoh
Oct 9, 1998·The Journal of Biological Chemistry·H R StennickeG S Salvesen
Apr 18, 1998·The Journal of Biological Chemistry·J M ZapataJ C Reed
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·J R BiggsA S Kraft
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·S J RiedlW Bode
Jun 26, 2003·The Journal of Biological Chemistry·Jean-Bernard Denault, Guy S Salvesen
Sep 3, 2003·European Journal of Biochemistry·Ming ZhaoUlf T Brunk
Jul 5, 2005·Expert Opinion on Investigational Drugs·L Denner
Nov 16, 2010·Cellular and Molecular Life Sciences : CMLS·M Lubka-PathakT Schimmang
Aug 9, 2012·The Journal of Biological Chemistry·Julie A ZornJames A Wells
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·G S Salvesen, V M Dixit
Feb 15, 2002·British Journal of Haematology·E C MorrisP B Coughlin
Dec 6, 2000·Microbiology and Molecular Biology Reviews : MMBR·H Y Chang, X Yang
Jul 12, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ken-ichiro HashimotoHidetaka Sakai
Sep 29, 2004·The Biochemical Journal·Pablo Fuentes-Prior, Guy S Salvesen
Apr 20, 2004·Journal of Cellular Physiology·William F HolmesKenneth J Soprano
Jan 21, 2003·The Journal of Biological Chemistry·Jowita MikolajczykGuy S Salvesen
Feb 13, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K-F HsuC-Y Chou
Nov 20, 2002·Biological Chemistry·Boris TurkVito Turk
May 24, 2008·Tissue Antigens·M S J ManganP I Bird
Aug 22, 2007·Nature Chemical Biology·Jean-Bernard DenaultJennifer L Harris
Jan 30, 2008·Current Protocols in Cell Biology·S H KaufmannW C Earnshaw
Aug 26, 2014·Apoptosis : an International Journal on Programmed Cell Death·C ReutherC Culmsee
Dec 10, 2015·The FEBS Journal·Guy S SalvesenNuria S Coll

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