PMID: 8962088Dec 10, 1996Paper

Activation of protein kinase A-independent pathways by Gs alpha in Drosophila

Proceedings of the National Academy of Sciences of the United States of America
W J WolfgangMichael Forte

Abstract

One of the best-described transmembrane signal transduction mechanisms is based on receptor activation of the alpha subunit of the heterotrimeric G protein Gs, leading to stimulation of adenylyl cyclase and the production of cAMP. Intracellular cAMP is then thought to mediate its effects largely, if not entirely, by activation of protein kinase A and the subsequent phosphorylation of substrates which in turn control diverse cellular phenomena. In this report we demonstrate, by two different methods, that reduction or elimination of protein kinase A activity had no effect on phenotypes generated by activation of Gs alpha pathways in Drosophila wing epithelial cells. These genetic studies show that the Gs alpha pathway mediates its primary effects by a novel pathway in differentiating, wing epithelial cells. This novel pathway may in part be responsible for some of the complex, cell-specific responses observed following activation of this pathway in different cell types.

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Citations

Feb 14, 2002·Trends in Cardiovascular Medicine·Yong Chao Ma, Xin Yun Huang
Dec 5, 2006·Learning & Memory·Rusiko BourtchouladzeTed Abel
Sep 3, 2010·PloS One·Natalya KatanayevaVladimir L Katanaev
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y C Ma, X Y Huang
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·A FossgreenR Paro
Feb 1, 2012·Genesis : the Journal of Genetics and Development·Oleksii O BilousovVladimir L Katanaev
May 5, 2006·Journal of Neuroscience Research·Chunnian ZhaoPeter P Li
Jan 12, 2012·Food & Function·Hanaa H Abd El-Baky, Gamal S El-Baroty
Apr 18, 2000·The Journal of Biological Chemistry·C GuX Y Huang
Mar 13, 2020·PLoS Biology·Alexis T WeinerMelissa M Rolls
Mar 22, 2003·Journal of Chromatography. a·E K M UedaL Morganti
Jul 17, 2001·Genetics·W J WolfgangM Forte

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