PMID: 13549649Jul 1, 1958Paper

Activation of quiescent mucormycotic granulomata in rabbits by induction of acute alloxan diabetes

The Journal of Experimental Medicine
W H Sheldon, H Bauer

Abstract

In normal rabbits subcutaneous granulomata produced by the injection of a spore suspension of Rhizopus oryzae remained confined to the site of inoculation, showed no fungus proliferation, no longer yielded the agent on culture 10 weeks after inoculation, and eventually healed. Similar well established granulomata in rabbits with acute alloxan diabetes induced 8, 10, and 15 days after injection of the fungus uniformly showed activation of the infection. This occurred only in animals showing acetonuria. In these animals the skin lesions showed proliferation of the fungus frequently associated with invasion and early necrosis of the granuloma wall. In some instances, spread of the infection to adjacent tissues with invasion of blood vessels had occurred. These experiments illustrate that changes in host metabolism can activate a preexisting quiescent infection.

References

Oct 1, 1957·The Journal of Experimental Medicine·H BAUER, W H SHELDON

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Citations

Apr 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N Khardori
Nov 23, 1967·The New England Journal of Medicine·D B Louria
Sep 1, 1963·Disease-a-month : DM·J P UTZ
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Feb 1, 1986·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·O E Brown, R Finn
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Apr 3, 2019·Journal of Fungi·Ilse D Jacobsen
Jan 1, 1981·Mykosen·V M MahajanY Dayal
Jul 29, 2020·Journal de mycologie médicale·K Brunet, B Rammaert
Dec 1, 1982·Infection and Immunity·R S MarxS K Hentz
Oct 1, 1982·Infection and Immunity·R D DiamondN F Erickson

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