Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine.

The Journal of Biological Chemistry
Istvan BoldoghSankar Mitra

Abstract

8-Oxo-7,8-dihydroguanine (8-oxoG), arguably the most abundant base lesion induced in mammalian genomes by reactive oxygen species, is repaired via the base excision repair pathway that is initiated with the excision of 8-oxoG by OGG1. Here we show that OGG1 binds the 8-oxoG base with high affinity and that the complex then interacts with canonical Ras family GTPases to catalyze replacement of GDP with GTP, thus serving as a guanine nuclear exchange factor. OGG1-mediated activation of Ras leads to phosphorylation of the mitogen-activated kinases MEK1,2/ERK1,2 and increasing downstream gene expression. These studies document for the first time that in addition to its role in repairing oxidized purines, OGG1 has an independent guanine nuclear exchange factor activity when bound to 8-oxoG.

References

Jul 30, 1992·Nature·J M KyriakisJ Avruch
Mar 23, 1995·Molecular and Cellular Biochemistry·T K Chataway, G J Barritt
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·M K ShigenagaB N Ames
Mar 1, 1993·Molecular and Cellular Biology·C C LaiS Powers
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·T A RosenquistA P Grollman
Aug 5, 1998·Nature·F Wittinghofer
Aug 5, 1998·Nature·P A Boriack-SjodinJ Kuriyan
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·A KlunglandD E Barnes
Mar 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·O MinowaT Noda
Jun 13, 2001·Methods in Enzymology·S J TaylorD Shalloway
Nov 10, 2001·Science·I R Vetter, A Wittinghofer
Feb 28, 2002·Methods : a Companion to Methods in Enzymology·D JuzumieneP Wollenzien
Aug 13, 2002·Nature Cell Biology·Nahum MellerMartin A Schwartz
Jan 29, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jon G MableyCsaba Szabó
Aug 3, 2005·The Journal of Clinical Investigation·Istvan BoldoghSanjiv Sur
Oct 14, 2005·The Journal of Biological Chemistry·Jingping HuVilhelm A Bohr
Jun 22, 2007·Nature·Sheila S DavidSucharita Kundu
Jul 30, 2008·The Journal of Biological Chemistry·Muralidhar L HegdeSankar Mitra

❮ Previous
Next ❯

Citations

Apr 4, 2013·Antioxidants & Redox Signaling·Carolin CorneliusSalvatore Cuzzocrea
Sep 14, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara L ParsonsMartha M Moore
Dec 18, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Masahiro HashizumeJames C Parker
Jan 5, 2014·PloS One·Ramkumar MenonRobert N Taylor
Aug 2, 2013·Antioxidants & Redox Signaling·Timothy L ScottTadahide Izumi
Sep 25, 2014·International Journal of Molecular Sciences·Xueqing BaIstvan Boldogh
Jul 19, 2015·Free Radical Biology & Medicine·Leopoldo Aguilera-AguirreIstvan Boldogh
Nov 1, 2015·Nucleic Acids Research·Nicholas C BauerPaul W Doetsch
Sep 17, 2013·Environmental and Molecular Mutagenesis·Malathi BandaBarbara L Parsons
Mar 5, 2014·American Journal of Reproductive Immunology : AJRI·Ramkumar MenonIstvan Boldogh
Jan 15, 2014·Critical Reviews in Biochemistry and Molecular Biology·Dawit KidaneJoann B Sweasy
Aug 2, 2015·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Malathi BandaBarbara L Parsons
Jan 24, 2013·Free Radical Biology & Medicine·Zsolt RadakIstvan Boldogh
Jul 25, 2012·Cell Cycle·Michael G Kemp, Aziz Sancar
May 2, 2014·DNA Repair·Susan S Wallace
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·Fabrícia Lima FontesLucymara Fassarella Agnez-Lima
Dec 17, 2014·Frontiers in Aging Neuroscience·Jesús AvilaEduardo Soriano
May 26, 2016·Nucleic Acids Research·Julia AllgayerAndriy Khobta
Jun 3, 2016·Cellular Signalling·Xiaolong ZhouZhigang Guo
Jun 18, 2016·DNA Repair·Sean G RuddThomas Helleday
Jun 28, 2016·Mechanisms of Ageing and Development·Peter GermanIstvan Boldogh
Jun 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Peter G WellsLutfiya Miller-Pinsler
Oct 28, 2016·Photochemistry and Photobiology·Michael G Kemp, Jinchuan Hu
Dec 9, 2014·Current Opinion in Allergy and Clinical Immunology·Xueqing BaIstvan Boldogh
Jul 8, 2016·Circulation Research·Gantsetseg TumurkhuuMoshe Arditi
May 9, 2019·Environmental and Molecular Mutagenesis·Álvaro Gómez-TomásUNKNOWN PANKRAS II Study Group
Jul 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Kyung-Taek Rim
Oct 4, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Viktor M PastukhMark N Gillespie
Dec 24, 2015·Current Opinion in Allergy and Clinical Immunology·Attila BacsiIstvan Boldogh
May 2, 2020·International Journal of Molecular Sciences·Grigory V MechetinDmitry O Zharkov
Feb 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xueqing BaIstvan Boldogh
Jun 22, 2012·Journal of Cellular Physiology·Ian D OdellDavid S Pederson
Aug 12, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Leopoldo Aguilera-AguirreIstvan Boldogh
Apr 8, 2020·BioMed Research International·Gitana Maria AcetoMaria Cristina Curia

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.