Activation of renin-angiotensin-aldosterone system (RAAS) in the lung of smoking-induced pulmonary arterial hypertension (PAH) rats

Journal of the Renin-angiotensin-aldosterone System : JRAAS
Yi-Ming YuanChuan Luo

Abstract

To explore the role of the renin-angiotensin-aldosterone system (RAAS) in the pathogenesis of pulmonary arterial hypertension (PAH) induced by chronic exposure to cigarette smoke. 48 healthy male SD rats were randomly divided into four groups (12/group): control group (group A); inhibitor alone group (group B); cigarette induction group (group C); cigarette induction + inhibitor group (group D). After the establishment of smoking-induced PAH rat model, the right ventricular systolic pressure (RVSP) was detected using an inserted catheter; western blotting was used to detect the protein expression of angiotensin-converting enzyme-2 (ACE2) and angiotensin-converting enzyme (ACE); expression levels of angiotensin II (AngII) in lung tissue were measured by radioimmunoassay. After six months of cigarette exposure, the RVSP of chronic cigarette induction group was significantly higher than that of the control group; expression levels of AngII and ACE increased in lung tissues, but ACE2 expression levels reduced. Compared with cigarette exposure group, after losartan treatment, RVSP, ACE and AngII obviously decreased (P<0.05), and ACE2 expression levels significantly increased. Chronic cigarette exposure may result in PAH and affect t...Continue Reading

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Citations

Sep 1, 2015·Journal of Cardiovascular Pharmacology·Colleen T Cole-JeffreyVinayak Shenoy
Aug 9, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joshua M OakesXinping Yue
Jan 11, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ruifeng ZhangLiuhong Shi
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