Activation of renin synthesis is dependent on intact nitric oxide production

Kidney International
P L TharauxC Chatziantoniou

Abstract

The present study investigated whether or not nitric oxide (NO) synthesis mediates mechanisms regulating activation of renin formation. Studies were performed on afferent arterioles freshly isolated from the rat kidney. We have shown previously that this preparation is a useful model to study regulation of renin synthesis and secretion. The expression of renin mRNA was assessed by ribonuclease protection assay, and total renin content and renin secretion by radioimmunoassay. In afferent arterioles isolated from rats treated with the angiotensin-converting enzyme inhibitor ramipril, renin mRNA levels, total renin content and renin secretion were increased threefold compared to untreated controls. Inhibition of NO-synthase by NG-nitro-L-arginine methyl ester (L-NAME) in the ramipril-treated rats, abolished the increase in renin mRNA levels, total renin content and renin secretion. In other animals furosemide, a diuretic acting on macula densa cells, activated renin synthesis to a level similar to that found in the ramipril-treated group. Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanis...Continue Reading

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Citations

Aug 5, 1998·Current Opinion in Nephrology and Hypertension·C Wagner, A Kurtz
Jan 21, 2011·Physiological Reviews·Donald E KohanDavid M Pollock
Dec 18, 1998·Hypertension·R Zatz, C Baylis
Jan 18, 2006·The Japanese Journal of Physiology·Yukiko YasuokaKatsumasa Kawahara
Jan 16, 2007·European Journal of Endocrinology·Félix VargasJoaquín García-Estañ
Mar 21, 2002·Fundamental & Clinical Pharmacology·Tomohisa IshikawaKoichi Nakayama
May 10, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·N SaatE Sahna
Mar 3, 2007·Pharmacological Reviews·Noboru TodaTomio Okamura
Oct 26, 2018·Physiological Reviews·Agustin Gonzalez-VicenteJeffrey L Garvin
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
Mar 5, 1998·The American Journal of Physiology·J Schnermann
Apr 6, 2000·American Journal of Physiology. Renal Physiology·R A KrampN Caron
Dec 9, 1998·The American Journal of Physiology·A Kurtz, C Wagner
Dec 22, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A CasesJ C Romero
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Hayo CastropJurgen Schnermann
Aug 6, 2019·Frontiers in Pharmacology·Andrea SchrammJens Schlossmann

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