Activation of senescence-associated Dark-inducible (DIN) genes during infection contributes to enhanced susceptibility to plant viruses

Molecular Plant Pathology
Lourdes Fernández-CalvinoCésar Llave

Abstract

Virus infections in plants cause changes in host gene expression that are common to other environmental stresses. In this work, we found extensive overlap in the transcriptional responses between Arabidopsis thaliana plants infected with Tobacco rattle virus (TRV) and plants undergoing senescence. This is exemplified by the up-regulation during infection of several senescence-associated Dark-inducible (DIN) genes, including AtDIN1 (Senescence 1, SEN1), AtDIN6 (Asparagine synthetase 1, AtASN1) and AtDIN11. DIN1, DIN6 and DIN11 homologues were also activated in Nicotiana benthamiana in response to TRV and Potato virus X (PVX) infection. Reduced TRV levels in RNA interference (RNAi) lines targeting AtDIN11 indicate that DIN11 is an important modulator of susceptibility to TRV in Arabidopsis. Furthermore, low accumulation of TRV in Arabidopsis protoplasts from RNAi lines suggests that AtDIN11 supports virus multiplication in this species. The effect of DIN6 on virus accumulation was negligible in Arabidopsis, perhaps as a result of gene or functional redundancy. However, TRV-induced silencing of NbASN, the DIN6 homologue in N. benthamiana, compromises TRV and PVX accumulation in systemically infected leaves. Interestingly, NbASN in...Continue Reading

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Citations

Apr 27, 2016·Scientific Reports·Julia HillungSantiago F Elena
Aug 10, 2016·Genetics and Molecular Biology·Mercedes Diaz-MendozaIsabel Diaz
Jun 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Lotte CaarlsGuido Van den Ackerveken
Feb 2, 2017·BMC Plant Biology·Eric R SchultzRobert J Ferl
Dec 19, 2017·Journal of Experimental Botany·Seher YolcuYun Ju Kim
Jul 6, 2019·Molecular Plant Pathology·Laura Diezma-NavasVirginia Ruiz-Ferrer
Jan 24, 2020·Frontiers in Plant Science·Maria L BorniegoDana E Martinez
Feb 26, 2021·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Aminallah TahmasebiMuhammad Shafiq Shahid

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