Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.

FEBS Letters
Pamela W SteenE K LeMosy

Abstract

During Drosophila embryogenesis, establishment of ventral and lateral cell fates requires spatial regulation of an extracellular serine protease cascade composed of Nudel, Gastrulation Defective (GD), Snake, and Easter. Pipe, a sulfotransferase expressed ventrally during oogenesis, sulfates secreted targets that somehow confer positive spatial input to this cascade. Nudel and GD activation are pipe-independent, while Easter activation requires pipe. The effect of pipe on Snake activation has been unknown. Here we show that Snake activation is cascade-dependent but pipe-independent. These findings support a conclusion that Snake's activation of Easter is the first spatially regulated step in the dorsoventral protease cascade.

References

Dec 1, 1986·Molecular and Cellular Biology·T L Orr-Weaver, A C Spradling
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·K D KonradJ L Marsh
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y LiuB F Cravatt
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·J H HanC Hashimoto
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·E K LeMosyC Hashimoto
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nadim JessaniBenjamin F Cravatt
Dec 5, 2003·Current Biology : CB·Petros LigoxygakisJean-Marc Reichhart
Oct 25, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Ellen K LeMosy
Mar 28, 2008·Annual Review of Biochemistry·Benjamin F CravattJohn W Kozarich
May 15, 2008·Archives of Biochemistry and Biophysics·Sufang Tian, Ellen K LeMosy

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Citations

Aug 16, 2014·Wiley Interdisciplinary Reviews. Developmental Biology·David S Stein, Leslie M Stevens

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