Activation of soluble guanylyl cyclase by YC-1 in aortic smooth muscle but not in ventricular myocardium from rat

British Journal of Pharmacology
J W WegenerH Nawrath

Abstract

1. The effects of YC-1 (3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole), an activator of soluble guanylyl cyclase, on tension, levels of cyclic GMP and cyclic AMP, and cardiac L-type Ca2+-current (I[Ca(L)]) were investigated in aortic smooth muscle and ventricular heart muscle from rat. 2. YC-1 (0.1-30 microM) induced a concentration-dependent relaxation in aortic rings precontracted with phenylephrine (3 microM). The relaxant effects of YC-1 were reversed by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (30 microM; ODQ), potentiated by zaprinast (10 microM) and antagonized by Rp-8-Br-cGMPS (100 microM). 3. In ventricular heart muscle strips, YC-1 (30 microM) exhibited no effects on force of contraction (Fc) in the absence or presence of either zaprinast (10 microM) or 3-isobutyl-1-methylxanthine (30 microM). Fc was slightly increased by YC-1 (30 microM) in the presence of isoprenaline (100 nM), but this effect was not influenced by ODQ (30 microM). 4. Cardiac I[Ca(L)] was not significantly affected by YC-1 (30 microM), either in the absence or presence of isoprenaline (30 nM). 5. In aortic rings, cyclic GMP levels were increased almost 3 fold by YC-1 (30 microM); this effect was abolished by ODQ (30 microM). In isolated ventric...Continue Reading

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Citations

Oct 2, 2003·European Journal of Pharmacology·Juliana S BaracatGilberto De Nucci
Nov 11, 1999·European Journal of Pharmacology·S SeitzH Nawrath
Apr 7, 2012·Critical Care Research and Practice·Bobby NossamanPhilip Kadowitz
Nov 16, 2007·European Journal of Pharmacology·Tsong-Long HwangYen-Lin Pan
Nov 20, 2002·Expert Opinion on Pharmacotherapy·J S KalsiS Minhas
Sep 19, 2009·The Journal of Medical Investigation : JMI· YinhuaYutaka Nakaya
Jun 4, 1999·Nitric Oxide : Biology and Chemistry·E M BeckerJ P Stasch
Oct 5, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Sönke BehrendsRalf Middendorff
Mar 16, 2002·International Journal of Impotence Research·J D BrioniJ P Sullivan

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